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coq-1 Decaprenyl-diphosphate synthase subunit 2 [ Caenorhabditis elegans ]

Gene ID: 172190, updated on 23-Nov-2023

Summary

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Gene symbol
coq-1
Gene description
Decaprenyl-diphosphate synthase subunit 2
Primary source
WormBase:WBGene00000761
Locus tag
CELE_C24A11.9
See related
AllianceGenome:WB:WBGene00000761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable prenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be part of transferase complex. Is expressed in intestine. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2. Orthologous to human PDSS1 (decaprenyl diphosphate synthase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (5412841..5415629, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene Small-subunit processome Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dietary restriction decreases coenzyme Q and ubiquinol potentially via changes in gene expression in the model organism C. elegans. Fischer A, et al. Biofactors, 2015 May 6. PMID 25939481
  2. C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development. Gavilán A, et al. Biofactors, 2005. PMID 16873927
  3. Caenorhabditis elegans ubiquinone biosynthesis genes. Rodríguez-Aguilera JC, et al. Biofactors, 2003. PMID 14695939
  4. Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. Asencio C, et al. FASEB J, 2003 Jun. PMID 12709403
  5. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables prenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Decaprenyl-diphosphate synthase subunit 2
NP_491588.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5412841..5415629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059187.6 → NP_491588.1  Decaprenyl-diphosphate synthase subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91093
    Conserved Domains (1) summary
    pfam00348
    Location:80 → 344
    polyprenyl_synt; Polyprenyl synthetase
Nucleotide Protein
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