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Mcm4 minichromosome maintenance complex component 4 [ Mus musculus (house mouse) ]

Gene ID: 17217, updated on 8-Dec-2022

Summary

Official Symbol
Mcm4provided by MGI
Official Full Name
minichromosome maintenance complex component 4provided by MGI
Primary source
MGI:MGI:103199
See related
Ensembl:ENSMUSG00000022673 AllianceGenome:MGI:103199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
19G; Cdc21; Mcmd4; mcdc21; mKIAA4003
Summary
Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; future brain; limb; metanephros; and myocardium layer. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 36.5), liver E14.5 (RPKM 34.4) and 21 other tissues See more
Orthologs
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Genomic context

See Mcm4 in Genome Data Viewer
Location:
16 A2; 16 10.09 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15441761..15455264, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15623897..15637400, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 Neighboring gene predicted gene 7748 Neighboring gene protein kinase, DNA activated, catalytic polypeptide Neighboring gene predicted gene, 52255 Neighboring gene mitotic spindle organizing protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4003

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables single-stranded DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within DNA unwinding involved in DNA replication IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated DNA replication initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
 
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM4
Names
CDC21 homolog
P1-CDC21
mini chromosome maintenance deficient 4 homolog
minichromosome maintenance deficient 4 homolog
NP_032591.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008565.3NP_032591.3  DNA replication licensing factor MCM4

    See identical proteins and their annotated locations for NP_032591.3

    Status: VALIDATED

    Source sequence(s)
    AK036653, AK141644, AK151499
    Consensus CDS
    CCDS27977.1
    UniProtKB/Swiss-Prot
    O89056, P49717
    UniProtKB/TrEMBL
    Q3UA65, Q542F4
    Related
    ENSMUSP00000023353.4, ENSMUST00000023353.4
    Conserved Domains (3) summary
    smart00350
    Location:266769
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:165286
    MCM_N; MCM N-terminal domain
    cl21455
    Location:504643
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    15441761..15455264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)