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Mcm2 minichromosome maintenance complex component 2 [ Mus musculus (house mouse) ]

Gene ID: 17216, updated on 1-Mar-2024

Summary

Official Symbol
Mcm2provided by MGI
Official Full Name
minichromosome maintenance complex component 2provided by MGI
Primary source
MGI:MGI:105380
See related
Ensembl:ENSMUSG00000002870 AllianceGenome:MGI:105380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BM28; CDCL1; Mcmd2; mKIAA0030
Summary
Enables DNA replication origin binding activity; enzyme binding activity; and histone binding activity. Acts upstream of or within DNA unwinding involved in DNA replication; cellular response to interleukin-4; and nucleosome assembly. Located in nucleus. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including central nervous system; future brain; inner cell mass; limb; and vertebral axis musculature. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 77.8), liver E14 (RPKM 74.1) and 21 other tissues See more
Orthologs
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Genomic context

See Mcm2 in Genome Data Viewer
Location:
6 D1; 6 39.64 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88860456..88875762, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88883474..88898780, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene predicted gene 15612 Neighboring gene podocalyxin-like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88836578-88836779 Neighboring gene STARR-positive B cell enhancer ABC_E2794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88852049-88852232 Neighboring gene transmembrane protein, adipocyte asscociated 1 Neighboring gene predicted gene, 36268

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA replication initiation TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cochlea development ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in premeiotic DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
 
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM2
Names
mini chromosome maintenance deficient 2
minichromosome maintenance deficient 2 mitotin
minichromosome maintenance protein 2 homolog
nuclear protein BM28
NP_032590.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008564.2NP_032590.2  DNA replication licensing factor MCM2

    See identical proteins and their annotated locations for NP_032590.2

    Status: VALIDATED

    Source sequence(s)
    AK129039, BY324067, CK378639
    Consensus CDS
    CCDS39554.1
    UniProtKB/Swiss-Prot
    O08971, O89057, P97310, Q8C2R0
    UniProtKB/TrEMBL
    Q3UJN1
    Related
    ENSMUSP00000061923.7, ENSMUST00000058011.8
    Conserved Domains (4) summary
    smart00350
    Location:291803
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:72182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:198310
    MCM_N; MCM N-terminal domain
    cl21455
    Location:485632
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88860456..88875762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)