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Mcm2 minichromosome maintenance complex component 2 [ Mus musculus (house mouse) ]

Gene ID: 17216, updated on 25-Sep-2020

Summary

Official Symbol
Mcm2provided by MGI
Official Full Name
minichromosome maintenance complex component 2provided by MGI
Primary source
MGI:MGI:105380
See related
Ensembl:ENSMUSG00000002870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BM28; CDCL; CDCL1; Mcmd2; AA959861; AW476101; mKIAA0030
Expression
Broad expression in liver E14.5 (RPKM 77.8), liver E14 (RPKM 74.1) and 21 other tissues See more
Orthologs

Genomic context

See Mcm2 in Genome Data Viewer
Location:
6; 6 D1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88860456..88875762, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88883474..88898780, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (88833468..88848774, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and BTB (POZ) domain containing 1 Neighboring gene predicted gene 15612 Neighboring gene podocalyxin-like 2 Neighboring gene transmembrane protein, adipocyte asscociated 1 Neighboring gene predicted gene, 36268

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
DNA replication initiation TAS
Traceable Author Statement
more info
PubMed 
DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
cochlea development ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM complex ISO
Inferred from Sequence Orthology
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA replication licensing factor MCM2
Names
mini chromosome maintenance deficient 2
minichromosome maintenance deficient 2 mitotin
minichromosome maintenance protein 2 homolog
nuclear protein BM28
NP_032590.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008564.2NP_032590.2  DNA replication licensing factor MCM2

    See identical proteins and their annotated locations for NP_032590.2

    Status: VALIDATED

    Source sequence(s)
    AK129039, BY324067, CK378639
    Consensus CDS
    CCDS39554.1
    UniProtKB/Swiss-Prot
    P97310
    Related
    ENSMUSP00000061923.6, ENSMUST00000058011.7
    Conserved Domains (4) summary
    smart00350
    Location:291803
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:72182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:198310
    MCM_N; MCM N-terminal domain
    cl21455
    Location:485632
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88860456..88875762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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