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Mc4r melanocortin 4 receptor [ Mus musculus (house mouse) ]

Gene ID: 17202, updated on 31-Jan-2023

Summary

Official Symbol
Mc4rprovided by MGI
Official Full Name
melanocortin 4 receptorprovided by MGI
Primary source
MGI:MGI:99457
See related
Ensembl:ENSMUSG00000047259 AllianceGenome:MGI:99457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcp; Mc4-r
Summary
This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]
Orthologs
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Genomic context

See Mc4r in Genome Data Viewer
Location:
18; 18 E1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66990776..66993558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (66857705..66860487, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41762 Neighboring gene predicted gene, 22219 Neighboring gene predicted gene, 30190 Neighboring gene predicted gene, 19784 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables melanocortin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables melanocortin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables melanocyte-stimulating hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables melanocyte-stimulating hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables melanocyte-stimulating hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in diet induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of grooming behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to melanocyte-stimulating hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016977.4NP_058673.2  melanocortin receptor 4

    See identical proteins and their annotated locations for NP_058673.2

    Status: REVIEWED

    Source sequence(s)
    AK136793, BB633776, BY646801
    Consensus CDS
    CCDS29316.1
    UniProtKB/Swiss-Prot
    P56450, Q9EQM7
    UniProtKB/TrEMBL
    A0A6P5NZN9, Q49NQ7
    Related
    ENSMUSP00000054776.3, ENSMUST00000057942.4
    Conserved Domains (1) summary
    cd15353
    Location:45313
    7tmA_MC4R; melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    66990776..66993558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)