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unc-73 hypothetical protein [ Caenorhabditis elegans ]

Gene ID: 171988, updated on 19-Oct-2019

Summary

Gene symbol
unc-73
Gene description
hypothetical protein
Primary source
WormBase:WBGene00006805
Locus tag
CELE_F55C7.7
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See unc-73 in Genome Data Viewer
Location:
chromosome: I
Exon count:
37
Sequence:
Chromosome: I; NC_003279.8 (3999300..4031739, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Calponin-homology (CH) domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Muscle M-line assembly protein unc-89 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
Rac GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rac guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rho GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rac protein signal transduction IC
Inferred by Curator
more info
PubMed 
cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration TAS
Traceable Author Statement
more info
PubMed 
embryo development ending in birth or egg hatching NAS
Non-traceable Author Statement
more info
PubMed 
engulfment of apoptotic cell IGI
Inferred from Genetic Interaction
more info
PubMed 
male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesodermal cell migration TAS
Traceable Author Statement
more info
PubMed 
motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
nematode larval development NAS
Non-traceable Author Statement
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IPI
Inferred from Physical Interaction
more info
PubMed 
neuron migration TAS
Traceable Author Statement
more info
PubMed 
oviposition TAS
Traceable Author Statement
more info
PubMed 
positive regulation of Rac protein signal transduction IC
Inferred by Curator
more info
PubMed 
positive regulation of Rho protein signal transduction IC
Inferred by Curator
more info
PubMed 
positive regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vulval development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
muscle cell projection IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hypothetical protein
NP_001021496.1
  • Confirmed by transcript evidence
NP_001021497.1
  • Confirmed by transcript evidence
NP_001021498.1
  • Confirmed by transcript evidence
NP_001021499.1
  • Confirmed by transcript evidence
NP_001021500.1
  • Confirmed by transcript evidence
NP_001249512.1
  • Confirmed by transcript evidence
NP_001249513.1
  • Confirmed by transcript evidence
NP_001249517.1
  • Confirmed by transcript evidence
NP_001361940.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3999300..4031739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026325.2NP_001021496.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021496.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61528
    Conserved Domains (11) summary
    smart00060
    Location:23952473
    FN3; Fibronectin type 3 domain
    smart00516
    Location:19156
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12081383
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam07679
    Location:23052391
    I-set; Immunoglobulin I-set domain
    cd13241
    Location:19902128
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:14191511
    PH; PH domain
    pfam00621
    Location:18131986
    RhoGEF; RhoGEF domain
    cl02488
    Location:422568
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl11960
    Location:23352392
    Ig; Immunoglobulin domain
    cl17036
    Location:15751634
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:13911509
    PH-like; Pleckstrin homology-like domain
  2. NM_001026327.3NP_001021498.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021498.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNG6
    Conserved Domains (6) summary
    smart00060
    Location:835913
    FN3; Fibronectin type 3 domain
    smart00326
    Location:1373
    SH3; Src homology 3 domains
    cd00160
    Location:250425
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam07679
    Location:745831
    I-set; Immunoglobulin I-set domain
    cd13241
    Location:430568
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cl11960
    Location:775832
    Ig; Immunoglobulin domain
  3. NM_001375256.1NP_001361940.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    Status: REVIEWED

  4. NM_001262583.2NP_001249512.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYM4
    Conserved Domains (5) summary
    smart00060
    Location:830908
    FN3; Fibronectin type 3 domain
    cd00160
    Location:245420
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam07679
    Location:740826
    I-set; Immunoglobulin I-set domain
    cd13241
    Location:425563
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cl11960
    Location:770827
    Ig; Immunoglobulin domain
  5. NM_001262588.2NP_001249517.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249517.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4ALD5
    Conserved Domains (8) summary
    smart00516
    Location:19156
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12081383
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:19902128
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:14191511
    PH; PH domain
    pfam00621
    Location:18131986
    RhoGEF; RhoGEF domain
    cl02488
    Location:422568
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:15751634
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:13911509
    PH-like; Pleckstrin homology-like domain
  6. NM_001262584.2NP_001249513.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249513.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYM2
    Conserved Domains (3) summary
    smart00326
    Location:1373
    SH3; Src homology 3 domains
    cd00160
    Location:250425
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:430568
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
  7. NM_001026329.4NP_001021500.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021500.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Q51
    Conserved Domains (2) summary
    cd00160
    Location:245420
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:425563
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
  8. NM_001026328.3NP_001021499.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021499.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNG4
    Conserved Domains (2) summary
    cd00160
    Location:164339
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:344482
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
  9. NM_001026326.2NP_001021497.1  Uncharacterized protein CELE_F55C7.7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021497.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KPP4
    Conserved Domains (6) summary
    smart00516
    Location:19156
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12081383
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam00169
    Location:14191511
    PH; PH domain
    cl02488
    Location:422568
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:15751634
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:13911509
    PH-like; Pleckstrin homology-like domain
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