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Mbl1 mannose-binding lectin (protein A) 1 [ Mus musculus (house mouse) ]

Gene ID: 17194, updated on 21-Apr-2024

Summary

Official Symbol
Mbl1provided by MGI
Official Full Name
mannose-binding lectin (protein A) 1provided by MGI
Primary source
MGI:MGI:96923
See related
Ensembl:ENSMUSG00000037780 AllianceGenome:MGI:96923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBL-A; MBP-A; S-MBP
Summary
Predicted to enable several functions, including calcium-dependent carbohydrate binding activity; mannose binding activity; and phosphatidylinositol-4-phosphate binding activity. Acts upstream of or within defense response to other organism and positive regulation of phagocytosis. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 28.0), liver E18 (RPKM 18.6) and 2 other tissues See more
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Genomic context

Location:
14 B; 14 22.36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40873413..40885861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (41151456..41163904)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene surfactant associated protein A1 Neighboring gene pleckstrin homology domain containing, family F (with FYVE domain) member 2 pseudogene Neighboring gene surfactant associated protein D Neighboring gene STARR-seq mESC enhancer starr_36478 Neighboring gene predicted gene, 31895

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mannose binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables polysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mannose-binding protein A
Names
mannan-binding protein
mannose binding lectin (A)
mannose binding lectin, serum (A)
ra-reactive factor polysaccharide-binding component p28B
raRF p28B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010775.2NP_034905.1  mannose-binding protein A precursor

    See identical proteins and their annotated locations for NP_034905.1

    Status: PROVISIONAL

    Source sequence(s)
    AC124400
    Consensus CDS
    CCDS26961.1
    UniProtKB/Swiss-Prot
    P39039, Q0P6H1
    Related
    ENSMUSP00000153147.2, ENSMUST00000225792.2
    Conserved Domains (2) summary
    cd03591
    Location:127237
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:3789
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    40873413..40885861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518669.4XP_006518732.1  mannose-binding protein A isoform X1

    See identical proteins and their annotated locations for XP_006518732.1

    UniProtKB/Swiss-Prot
    P39039, Q0P6H1
    Conserved Domains (2) summary
    cd03591
    Location:127237
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:3789
    Collagen; Collagen triple helix repeat (20 copies)