txl-1 Thioredoxin-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: txl-1
Official Full Name: Thioredoxin-like protein
Primary source: WormBase:WBGene00021826
Locus tag: CELE_Y54E10A.3
See related: AllianceGenome:WB:WBGene00021826
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-disulfide reductase activity. Predicted to be active in cytosol. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See txl-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (3229431..3233286)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-245 (e-PCR)
- UniSTS:241737

Y54E10A_155.b (e-PCR)
- UniSTS:323739

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Thioredoxin-like protein

NP_491127.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3229431..3233286

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058726.8 → NP_491127.1 Thioredoxin-like protein

See identical proteins and their annotated locations for NP_491127.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EES9, Q7KMR6

Conserved Domains (2) summary

cd02947
Location:10 → 103

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

pfam06201
Location:121 → 262

PITH; PITH domain