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arx-7 Actin-related protein 2/3 complex subunit 5 [ Caenorhabditis elegans ]

Gene ID: 171882, updated on 18-Sep-2024

Summary

Official Symbol
arx-7
Official Full Name
Actin-related protein 2/3 complex subunit 5
Primary source
WormBase:WBGene00000205
Locus tag
CELE_M01B12.3
See related
AllianceGenome:WB:WBGene00000205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; epithelial cell migration; and morphogenesis of embryonic epithelium. Located in cytoplasm. Is expressed in anchor cell; hypodermis; and linker cell. Orthologous to human ARPC5 (actin related protein 2/3 complex subunit 5) and ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See arx-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (3069325..3070150, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene Transporter Neighboring gene C2H2-type domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 1 Neighboring gene Ensconsin Neighboring gene Serine/threonine-protein kinase RIO1

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in Arp2/3 complex-mediated actin nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Actin-related protein 2/3 complex subunit 5
NP_001379803.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3069325..3070150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393172.1NP_001379803.1  Actin-related protein 2/3 complex subunit 5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61861
    Conserved Domains (1) summary
    pfam04699
    Location:9150
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)