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mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 [ Caenorhabditis elegans ]

Gene ID: 171872, updated on 19-Oct-2019

Summary

Gene symbol
mek-2
Gene description
Dual specificity mitogen-activated protein kinase kinase mek-2
Primary source
WormBase:WBGene00003186
Locus tag
CELE_Y54E10BL.6
Gene type
protein coding
RNA name
Dual specificity mitogen-activated protein kinase kinase mek-2
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See mek-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (3005403..3013448, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SUPpressor of Rpm-1 Neighboring gene DNaJ domain (prokaryotic heat shock protein) Neighboring gene NADH Ubiquinone oxidoreductase Fe-S protein Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene RNA-binding protein NOB1 Neighboring gene RING-type domain-containing protein Neighboring gene Signal peptidase complex catalytic subunit SEC11

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the mek-2 gene: The mek-2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
oogenesis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vulval development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Dual specificity mitogen-activated protein kinase kinase mek-2
NP_491087.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3005403..3013448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058686.5NP_491087.1  Dual specificity mitogen-activated protein kinase kinase mek-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491087.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10664
    Conserved Domains (2) summary
    cd06615
    Location:71380
    PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase
    smart00220
    Location:74360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
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