mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mek-2
Official Full Name: Dual specificity mitogen-activated protein kinase kinase mek-2
Primary source: WormBase:WBGene00003186
Locus tag: CELE_Y54E10BL.6
See related: AllianceGenome:WB:WBGene00003186
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine/tyrosine kinase activity and scaffold protein binding activity. Involved in defense response to Gram-positive bacterium; intracellular signaling cassette; and vulval development. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; cardiofaciocutaneous syndrome 4; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1) and MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mek-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (3005403..3013448, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans ERK kinase MPK-1 or ERK phosphorylating/activating kinase MEK-2 constitutively activates native ClC anion channel CLH-3b upstream from Gck-3.
Title: C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y54E10B_152.b (e-PCR)
- UniSTS:323102

Y54E10B_152.d (e-PCR)
- UniSTS:323103

Y54E10B_152.e (e-PCR)
- UniSTS:323104

Y54E10B_152.c (e-PCR)
- UniSTS:323741

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in vulval development	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: Dual specificity mitogen-activated protein kinase kinase mek-2

NP_491087.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3005403..3013448 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058686.5 → NP_491087.1 Dual specificity mitogen-activated protein kinase kinase mek-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491087.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10664

Conserved Domains (2) summary

cd06615
Location:71 → 380

PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase

smart00220
Location:74 → 360

S_TKc; Serine/Threonine protein kinases, catalytic domain