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Matn2 matrilin 2 [ Mus musculus (house mouse) ]

Gene ID: 17181, updated on 5-Jan-2022

Summary

Official Symbol
Matn2provided by MGI
Official Full Name
matrilin 2provided by MGI
Primary source
MGI:MGI:109613
See related
Ensembl:ENSMUSG00000022324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crtm2; matrilin-2
Summary
Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within neurogenesis and response to axon injury. Located in basement membrane. Is expressed in several structures, including brain; chondrocranium; forelimb; heart; and spinal cord meninges. Orthologous to human MATN2 (matrilin 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in bladder adult (RPKM 46.5), subcutaneous fat pad adult (RPKM 34.4) and 14 other tissues See more
Orthologs
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Genomic context

See Matn2 in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34306827..34436388)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34306681..34436242)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (34236436..34365997)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38594 Neighboring gene lysosomal-associated protein transmembrane 4B Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene Neighboring gene RIKEN cDNA 9430069I07 gene Neighboring gene predicted gene, 24523 Neighboring gene ribosomal protein L30 Neighboring gene glutamate rich 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102477

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358780.1NP_001345709.1  matrilin-2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC126028, AC133101, AC144632
    Consensus CDS
    CCDS88747.1
    Related
    ENSMUSP00000154040.2, ENSMUST00000227759.2
    Conserved Domains (4) summary
    cd01475
    Location:54276
    vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
    pfam10393
    Location:911953
    Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin
    pfam14670
    Location:570605
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:652892
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_016762.2NP_058042.2  matrilin-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK138211, AK163818, BY146293
    Consensus CDS
    CCDS37056.1
    UniProtKB/TrEMBL
    Q3TQ80
    Related
    ENSMUSP00000022947.6, ENSMUST00000022947.7
    Conserved Domains (4) summary
    cd01475
    Location:54276
    vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
    pfam10393
    Location:892934
    Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin
    pfam14670
    Location:570605
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:652873
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    34306827..34436388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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