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afd-1 PDZ domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171776, updated on 5-Sep-2019

Summary

Gene symbol
afd-1
Gene description
PDZ domain-containing protein
Primary source
WormBase:WBGene00021009
Locus tag
CELE_W03F11.6
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See afd-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
23
Sequence:
Chromosome: I; NC_003279.8 (2160042..2209637)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene Uterine Lumin Expressed/locailized Neighboring gene Receptor-type guanylate cyclase gcy-17

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PDZ domain-containing protein
NP_001021659.1
  • Confirmed by transcript evidence
NP_001021660.2
  • Confirmed by transcript evidence
NP_001021661.2
  • Confirmed by transcript evidence
NP_001293329.1
  • Confirmed by transcript evidence
NP_001293330.1
  • Partially confirmed by transcript evidence
NP_001293331.1
  • Partially confirmed by transcript evidence
NP_001293332.1
  • Partially confirmed by transcript evidence
NP_001293333.1
  • Partially confirmed by transcript evidence
NP_001293334.1
  • Confirmed by transcript evidence
NP_001293335.1
  • Confirmed by transcript evidence
NP_001293336.1
  • Confirmed by transcript evidence
NP_001293337.1
  • Confirmed by transcript evidence
NP_001293458.1
  • Partially confirmed by transcript evidence
NP_001343732.1
  • Partially confirmed by transcript evidence
NP_490938.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2160042..2209637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026489.5NP_001021660.2  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021660.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NJ4
    Conserved Domains (5) summary
    cd01782
    Location:15126
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:354457
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:9731054
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:566867
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:218319
    UBQ; Ubiquitin-like proteins
  2. NM_001306400.2NP_001293329.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293329.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LPT9
    Conserved Domains (5) summary
    cd01782
    Location:15126
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:354457
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:9731054
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:566867
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:218319
    UBQ; Ubiquitin-like proteins
  3. NM_058537.5NP_490938.3  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490938.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIC1
    Conserved Domains (5) summary
    cd01782
    Location:15126
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:352455
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:9711052
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:564865
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:216317
    UBQ; Ubiquitin-like proteins
  4. NM_001026490.5NP_001021661.2  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021661.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NJ3
    Conserved Domains (5) summary
    cd01782
    Location:15126
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:352455
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:9711052
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:564865
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:216317
    UBQ; Ubiquitin-like proteins
  5. NM_001356800.2NP_001343732.1  PDZ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (5) summary
    cd00060
    Location:192295
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:811892
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:404705
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam11702
    Location:10121078
    DUF3295; Protein of unknown function (DUF3295)
    cl00155
    Location:107157
    UBQ; Ubiquitin-like proteins
  6. NM_001306401.2NP_001293330.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293330.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LX70
    Conserved Domains (4) summary
    cd00060
    Location:76179
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:695776
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:288589
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:241
    UBQ; Ubiquitin-like proteins
  7. NM_001306402.2NP_001293331.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293331.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M5P8
    Conserved Domains (4) summary
    cd00060
    Location:76179
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:695776
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:288589
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:241
    UBQ; Ubiquitin-like proteins
  8. NM_001306403.2NP_001293332.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M8U5
    Conserved Domains (3) summary
    cd00060
    Location:14117
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:633714
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:226527
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  9. NM_001306404.2NP_001293333.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293333.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LV54
    Conserved Domains (3) summary
    cd00060
    Location:14117
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:633714
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:226527
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  10. NM_001306405.2NP_001293334.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293334.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LPU4
    Conserved Domains (2) summary
    cd00992
    Location:540621
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:133434
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  11. NM_001306406.2NP_001293335.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293335.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LX73
    Conserved Domains (2) summary
    cd00992
    Location:540621
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:133434
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  12. NM_001306529.2NP_001293458.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293458.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M1ZJY5
    Conserved Domains (2) summary
    cd00992
    Location:565646
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:158459
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  13. NM_001306407.2NP_001293336.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293336.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M5Q5
    Conserved Domains (2) summary
    cd00992
    Location:458539
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:51352
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  14. NM_001306408.2NP_001293337.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293337.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M8V1
    Conserved Domains (2) summary
    cd00992
    Location:458539
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:51352
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  15. NM_001026488.3NP_001021659.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021659.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIC0
    Conserved Domains (1) summary
    cd00992
    Location:872
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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