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Epcam epithelial cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 171577, updated on 21-Jul-2018

Summary

Official Symbol
Epcamprovided by RGD
Official Full Name
epithelial cell adhesion moleculeprovided by RGD
Primary source
RGD:621365
See related
Ensembl:ENSRNOG00000015667
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Egp314; Tacstd1
Summary
involved in metastasis formation and tumor progression [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 1135.4), Lung (RPKM 204.7) and 2 other tissues See more
Orthologs

Genomic context

See Epcam in Genome Data Viewer
Location:
6q12
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (11282194..11308870, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (21264116..21280078, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692554 Neighboring gene uncharacterized LOC102555012 Neighboring gene uncharacterized LOC103692555 Neighboring gene mutS homolog 2 Neighboring gene potassium two pore domain channel subfamily K member 12 Neighboring gene F-box only protein 11-like Neighboring gene uncharacterized LOC103692557

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cadherin binding involved in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding involved in cell-cell adhesion IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell-cell adhesion via plasma-membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epithelial cell adhesion molecule
Names
ep-CAM
epithelial glycoprotein 314
tumor-associated calcium signal transducer 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138541.1NP_612550.1  epithelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_612550.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ001044
    UniProtKB/Swiss-Prot
    O55159
    Related
    ENSRNOP00000021135.5, ENSRNOT00000021135.6
    Conserved Domains (1) summary
    cd00191
    Location:65125
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    11282194..11308870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594027.1XP_017449516.1  epithelial cell adhesion molecule isoform X1

    UniProtKB/Swiss-Prot
    O55159
    Conserved Domains (1) summary
    cd00191
    Location:65125
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    6637498..6653429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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