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Dnm3 dynamin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171574, updated on 12-Jan-2022

Summary

Official Symbol
Dnm3provided by RGD
Official Full Name
dynamin 3provided by RGD
Primary source
RGD:727949
See related
Ensembl:ENSRNOG00000026490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
dynamin-2
Summary
Enables G protein-coupled glutamate receptor binding activity; GTPase activity; and nitric-oxide synthase binding activity. A structural constituent of postsynapse. Involved in several processes, including filopodium assembly; postsynaptic neurotransmitter receptor internalization; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including dendritic spine head; postsynaptic density; and synaptic cleft. Part of apical tubulobulbar complex and basal tubulobulbar complex. Is active in glutamatergic synapse and postsynaptic endocytic zone membrane. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 130.7), Adrenal (RPKM 65.1) and 7 other tissues See more
Orthologs
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Genomic context

See Dnm3 in Genome Data Viewer
Location:
13q22
Exon count:
24
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (74359043..74838135, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (79906711..80379967, complement)

Chromosome 13 - NC_051348.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692015 Neighboring gene similar to hypothetical protein Neighboring gene uncharacterized LOC102554129 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microRNA 199a-2 Neighboring gene microRNA 3120 Neighboring gene microRNA 214 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102554073 Neighboring gene uncharacterized LOC102555077 Neighboring gene uncharacterized LOC120096298

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitric-oxide synthase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables type 1 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 5 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
part_of apical tubulobulbar complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
part_of basal tubulobulbar complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine head IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynamin-3
Names
T-dynamin
dynamin, testicular
testicular dynamin
NP_612547.1
XP_006250203.1
XP_006250204.1
XP_017454151.1
XP_017454152.1
XP_017454153.1
XP_038946239.1
XP_038946240.1
XP_038946241.1
XP_038946244.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138538.2NP_612547.1  dynamin-3

    See identical proteins and their annotated locations for NP_612547.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000244
    UniProtKB/Swiss-Prot
    Q08877
    Related
    ENSRNOP00000063767.1, ENSRNOT00000067653.4
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79744
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam04554
    Location:769832
    Extensin_2; Extensin-like region
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051348.1 Reference mRatBN7.2 Primary Assembly

    Range
    74359043..74838135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090311.1XP_038946239.1  dynamin-3 isoform X4

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:661749
    GED; Dynamin GTPase effector domain
    pfam06346
    Location:757842
    Drf_FH1; Formin Homology Region 1
  2. XM_006250141.4XP_006250203.1  dynamin-3 isoform X5

    UniProtKB/Swiss-Prot
    Q08877
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79734
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam04554
    Location:759822
    Extensin_2; Extensin-like region
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647735
    GED; Dynamin GTPase effector domain
  3. XM_017598663.2XP_017454152.1  dynamin-3 isoform X2

  4. XM_017598662.2XP_017454151.1  dynamin-3 isoform X1

  5. XM_006250142.4XP_006250204.1  dynamin-3 isoform X6

    See identical proteins and their annotated locations for XP_006250204.1

    UniProtKB/Swiss-Prot
    Q08877
    Related
    ENSRNOP00000088404.1, ENSRNOT00000104847.1
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79734
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647735
    GED; Dynamin GTPase effector domain
    pfam10630
    Location:749837
    DUF2476; Protein of unknown function (DUF2476)
  6. XM_017598664.2XP_017454153.1  dynamin-3 isoform X3

    Related
    ENSRNOP00000068044.2, ENSRNOT00000075938.2
  7. XM_039090312.1XP_038946240.1  dynamin-3 isoform X7

    Conserved Domains (2) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
  8. XM_039090313.1XP_038946241.1  dynamin-3 isoform X7

    Conserved Domains (2) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
  9. XM_039090316.1XP_038946244.1  dynamin-3 isoform X8

    Conserved Domains (2) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216498
    Dynamin_M; Dynamin central region
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