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Man1a2 mannosidase, alpha, class 1A, member 2 [ Mus musculus (house mouse) ]

Gene ID: 17156, updated on 5-Aug-2018

Summary

Official Symbol
Man1a2provided by MGI
Official Full Name
mannosidase, alpha, class 1A, member 2provided by MGI
Primary source
MGI:MGI:104676
See related
Ensembl:ENSMUSG00000008763 Vega:OTTMUSG00000007027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCR2; Man1b; AI428775; AI528764; AI854422
Expression
Ubiquitous expression in cortex adult (RPKM 10.1), frontal lobe adult (RPKM 9.4) and 28 other tissues See more
Orthologs

Genomic context

See Man1a2 in Genome Data Viewer
Location:
3; 3 F2.2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (100562203..100685473, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (100366126..100489396, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5C Neighboring gene predicted gene 12474 Neighboring gene predicted gene, 40106 Neighboring gene predicted gene, 40107 Neighboring gene predicted gene, 32720 Neighboring gene V-set domain containing T cell activation inhibitor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
Names
alpha-1,2-mannosidase IB
mannosidase 1, beta
processing alpha-1,2-mannosidase IB
NP_034893.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010763.2NP_034893.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

    See identical proteins and their annotated locations for NP_034893.1

    Status: VALIDATED

    Source sequence(s)
    AK013515, AK041117, AK078047, AK078291, AK153336, BC068192, CB723579
    Consensus CDS
    CCDS17676.1
    UniProtKB/Swiss-Prot
    P39098
    Related
    ENSMUSP00000008907.7, OTTMUSP00000007449, ENSMUST00000008907.13, OTTMUST00000016265
    Conserved Domains (2) summary
    pfam01532
    Location:187626
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl26511
    Location:109208
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    100562203..100685473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187022.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    432296..555960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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