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Cxcl3 chemokine (C-X-C motif) ligand 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171551, updated on 18-Apr-2019

Summary

Official Symbol
Cxcl3provided by RGD
Official Full Name
chemokine (C-X-C motif) ligand 3provided by RGD
Primary source
RGD:621812
See related
Ensembl:ENSRNOG00000028043
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cinc2; Cinc-2; Gm1960
Summary
acts as a chemoattractant for neutrophils; involved in the inflammatory response [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1106.6) See more

Genomic context

See Cxcl3 in Genome Data Viewer
Location:
14p22
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18820168..18839659, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (18729345..18748734, complement)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548839 Neighboring gene similar to Alpha-enolase (2-phospho-D-glycerate hydro-lyase) (Non-neural enolase) (NNE) (Enolase 1) Neighboring gene uncharacterized LOC102549742 Neighboring gene platelet factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
neutrophil chemotaxis NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
C-X-C motif chemokine 3
Names
MIP2-alpha/beta
cytokine-induced neutrophil chemoattractant 2
macrophage inflammatory protein 2-alpha/beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138522.1NP_612531.1  C-X-C motif chemokine 3 precursor

    See identical proteins and their annotated locations for NP_612531.1

    Status: PROVISIONAL

    Source sequence(s)
    D21095
    UniProtKB/Swiss-Prot
    Q10746
    Related
    ENSRNOP00000038520.2, ENSRNOT00000034090.3
    Conserved Domains (1) summary
    cd00273
    Location:3496
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    18820168..18839659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250721.3XP_006250783.1  C-X-C motif chemokine 3 isoform X1

    See identical proteins and their annotated locations for XP_006250783.1

    UniProtKB/Swiss-Prot
    Q10746
    Related
    ENSRNOP00000070985.1, ENSRNOT00000078746.1
    Conserved Domains (1) summary
    cd00273
    Location:3496
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    16646603..16666030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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