U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Man1a mannosidase 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 17155, updated on 26-Sep-2022

Summary

Official Symbol
Man1aprovided by MGI
Official Full Name
mannosidase 1, alphaprovided by MGI
Primary source
MGI:MGI:104677
See related
Ensembl:ENSMUSG00000003746 AllianceGenome:MGI:104677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCR1; Man1a1
Summary
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; and protein targeting to ER. Located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb mesenchyme; and sensory organ. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 59.2), liver adult (RPKM 19.3) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Man1a in Genome Data Viewer
Location:
10; 10 B3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (53780881..53952712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (53904785..54076616, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184, member A Neighboring gene predicted gene, 53584 Neighboring gene predicted gene, 16998 Neighboring gene predicted gene, 40651 Neighboring gene predicted gene, 26177

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mannose trimming involved in glycoprotein ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to ER ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Names
alpha-1,2-mannosidase IA
man(9)-alpha-mannosidase
man9-mannosidase
mannosidase alpha class 1A member 1
mannosyl-oligosaccharide alpha-1,2-mannosidase
processing alpha-1,2-mannosidase IA
NP_032574.1
XP_006512631.1
XP_006512632.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008548.5NP_032574.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

    See identical proteins and their annotated locations for NP_032574.1

    Status: VALIDATED

    Source sequence(s)
    AC153816, AC158642, AC164624
    Consensus CDS
    CCDS23848.1
    UniProtKB/Swiss-Prot
    P45700
    UniProtKB/TrEMBL
    Q544T7
    Related
    ENSMUSP00000003843.9, ENSMUST00000003843.16
    Conserved Domains (2) summary
    pfam01532
    Location:204642
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl39091
    Location:87214
    SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    53780881..53952712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512568.3XP_006512631.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

    Related
    ENSMUSP00000151568.2, ENSMUST00000220088.2
    Conserved Domains (2) summary
    pfam01532
    Location:295733
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl39091
    Location:178305
    SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]
  2. XM_006512569.5XP_006512632.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

    See identical proteins and their annotated locations for XP_006512632.1

    UniProtKB/Swiss-Prot
    P45700
    UniProtKB/TrEMBL
    Q544T7
    Related
    ENSMUSP00000101110.2, ENSMUST00000105470.9
    Conserved Domains (2) summary
    pfam01532
    Location:204642
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl39091
    Location:87214
    SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

RNA

  1. XR_001779471.2 RNA Sequence