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Bmf BCL2 modifying factor [ Mus musculus (house mouse) ]

Gene ID: 171543, updated on 5-Mar-2024

Summary

Official Symbol
Bmfprovided by MGI
Official Full Name
BCL2 modifying factorprovided by MGI
Primary source
MGI:MGI:2176433
See related
Ensembl:ENSMUSG00000040093 AllianceGenome:MGI:2176433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in several processes, including negative regulation of autophagic cell death; negative regulation of autophagy; and positive regulation of cellular component organization. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of apoptotic signaling pathway. Located in actin cytoskeleton and cytoplasm. Part of myosin complex. Is expressed in pituitary gland. Orthologous to human BMF (Bcl2 modifying factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 8.9), thymus adult (RPKM 8.8) and 27 other tissues See more
Orthologs
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Genomic context

See Bmf in Genome Data Viewer
Location:
2 E5; 2 59.4 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118359238..118385240, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118528757..118549686, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05460 Neighboring gene STARR-positive B cell enhancer ABC_E10132 Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118325145-118325353 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118325384-118325664 Neighboring gene predicted gene, 32684 Neighboring gene STARR-positive B cell enhancer ABC_E9526 Neighboring gene STARR-positive B cell enhancer mm9_chr2:118372239-118372540 Neighboring gene STARR-positive B cell enhancer ABC_E1250 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118380077-118380314 Neighboring gene STARR-positive B cell enhancer ABC_E5963 Neighboring gene STARR-positive B cell enhancer ABC_E9527 Neighboring gene eukaryotic translation initiation factor 5A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8791 Neighboring gene BUB1B, mitotic checkpoint serine/threonine kinase Neighboring gene STARR-seq mESC enhancer starr_05463 Neighboring gene STARR-seq mESC enhancer starr_05464 Neighboring gene STARR-seq mESC enhancer starr_05465

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anoikis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of myosin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of myosin complex IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311140.3NP_001298069.1  bcl-2-modifying factor isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compard to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL929381
    Consensus CDS
    CCDS79835.1
    UniProtKB/TrEMBL
    A2AV74
    Related
    ENSMUSP00000106483.3, ENSMUST00000110859.3
    Conserved Domains (1) summary
    pfam15185
    Location:9188
    BMF; Bcl-2-modifying factor, apoptosis
  2. NM_001331221.2NP_001318150.1  bcl-2-modifying factor isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL929381
    Consensus CDS
    CCDS89538.1
    UniProtKB/Swiss-Prot
    Q8BUK0, Q91ZE9
    Related
    ENSMUSP00000159051.2, ENSMUST00000125860.3
    Conserved Domains (1) summary
    pfam15185
    Location:4183
    BMF; Bcl-2-modifying factor, apoptosis
  3. NM_001424740.1NP_001411669.1  bcl-2-modifying factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929381
    UniProtKB/Swiss-Prot
    Q8BUK0, Q91ZE9
  4. NM_001424741.1NP_001411670.1  bcl-2-modifying factor isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL929381
  5. NM_138313.5NP_612186.2  bcl-2-modifying factor isoform 1

    See identical proteins and their annotated locations for NP_612186.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL929381
    Consensus CDS
    CCDS16578.1
    UniProtKB/TrEMBL
    A2AV75
    Related
    ENSMUSP00000087686.7, ENSMUST00000090219.13
    Conserved Domains (1) summary
    pfam15185
    Location:90269
    BMF; Bcl-2-modifying factor, apoptosis

RNA

  1. NR_138603.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and differs at the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the open reading frame found in variant 1.
    Source sequence(s)
    AL929381

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118359238..118385240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159004.1XP_036014897.1  bcl-2-modifying factor isoform X2

    UniProtKB/Swiss-Prot
    Q8BUK0, Q91ZE9
    Conserved Domains (1) summary
    pfam15185
    Location:4183
    BMF; Bcl-2-modifying factor, apoptosis