Bmf BCL2 modifying factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmfprovided by MGI
Official Full Name: BCL2 modifying factorprovided by MGI
Primary source: MGI:MGI:2176433
See related: Ensembl:ENSMUSG00000040093 AllianceGenome:MGI:2176433
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Involved in several processes, including negative regulation of autophagic cell death; negative regulation of autophagy; and positive regulation of cellular component organization. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of apoptotic signaling pathway. Located in actin cytoskeleton and cytoplasm. Part of myosin complex. Is expressed in pituitary gland. Orthologous to human BMF (Bcl2 modifying factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 8.9), thymus adult (RPKM 8.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 E5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (118359238..118385280, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (118528757..118549686, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis.
Title: Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis.
Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.
Title: Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.
miR-29b binds to the 3'-UTR of Bmf.
Title: MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation.
In clinical Esophageal squamous cell carcinoma (ESCC)specimens, BMF expression was upregulated, and negatively correlated with that of miR-125b. In conclusion, miR-125b had an antitumor role in ESCC cells mediated by targeting BMF, which can be potentially useful for tumorigenesis in ESCC
Title: MicroRNA-125b inhibits cell proliferation and induces cell apoptosis in esophageal squamous cell carcinoma by targeting BMF.
demonstrate that this sudden and dramatic loss of primordial follicles is hormonally triggered and identify the pro-apoptotic BH3-only protein, BCL-2 modifying factor (BMF), as essential for this process, implicating the intrinsic apoptotic pathway as a key mechanism.
Title: The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF.
FOXO-dependent BMF expression is repressed in E-cadherin-negative and metastatic breast cancer cells and that expression of BMFis sufficient to inhibit tumour growth and dissemination in mice.
Title: Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer.
BMF loss is associated with germ cell loss during oogenesis.
Title: BCL2-modifying factor promotes germ cell loss during murine oogenesis.
Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf), mediate apoptosis in the context of TACI-Ig overexpression that effectively neutralizes BAFF as well as APRIL.
Title: Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice.
Bmf deficiency induced significant protection against oxygen/glucose deprivation injury in cultured neurons.
Title: Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury.
Our findings support an important role for BMF in determining the number of primordial follicles maintained in the ovary throughout adult reproductive life.
Title: Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW821977 (e-PCR)
- UniSTS:207382

D15S214 (e-PCR), detects polymorphism
- UniSTS:52050

AW411872 (e-PCR)
- UniSTS:178679

AW260063 (e-PCR)
- UniSTS:178680

Homology

Homologs of the Bmf gene: The Bmf gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 402 organisms have orthologs with human gene Bmf
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anoikis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: bcl-2-modifying factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311140.2 → NP_001298069.1 bcl-2-modifying factor isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compard to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AL929381

Consensus CDS

CCDS79835.1

UniProtKB/TrEMBL

A2AV74

Related

ENSMUSP00000106483.3, ENSMUST00000110859.3

Conserved Domains (1) summary

pfam15185
Location:9 → 188

BMF; Bcl-2-modifying factor, apoptosis
NM_001331221.1 → NP_001318150.1 bcl-2-modifying factor isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.

Source sequence(s)

AL929381

Consensus CDS

CCDS89538.1

UniProtKB/Swiss-Prot

Q8BUK0, Q91ZE9

UniProtKB/TrEMBL

A0A8C6GZM6

Related

ENSMUSP00000159051.2, ENSMUST00000125860.3

Conserved Domains (1) summary

pfam15185
Location:4 → 183

BMF; Bcl-2-modifying factor, apoptosis
NM_138313.4 → NP_612186.2 bcl-2-modifying factor isoform 1

See identical proteins and their annotated locations for NP_612186.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK040622, AK084658, AL929381

Consensus CDS

CCDS16578.1

UniProtKB/Swiss-Prot

Q91ZE9

UniProtKB/TrEMBL

A2AV75

Related

ENSMUSP00000087686.7, ENSMUST00000090219.13

Conserved Domains (1) summary

pfam15185
Location:90 → 269

BMF; Bcl-2-modifying factor, apoptosis

RNA

NR_138603.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and differs at the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the open reading frame found in variant 1.

Source sequence(s)

AL929381

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

118359238..118385280 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158999.1 → XP_036014892.1 bcl-2-modifying factor isoform X1

Conserved Domains (1) summary

pfam15185
Location:81 → 260

BMF; Bcl-2-modifying factor, apoptosis
XM_006498855.2 → XP_006498918.1 bcl-2-modifying factor isoform X2

See identical proteins and their annotated locations for XP_006498918.1

UniProtKB/Swiss-Prot

Q8BUK0, Q91ZE9

UniProtKB/TrEMBL

A0A8C6GZM6

Conserved Domains (1) summary

pfam15185
Location:4 → 183

BMF; Bcl-2-modifying factor, apoptosis
XM_036159004.1 → XP_036014897.1 bcl-2-modifying factor isoform X2

UniProtKB/Swiss-Prot

Q8BUK0

UniProtKB/TrEMBL

A0A8C6GZM6

Conserved Domains (1) summary

pfam15185
Location:4 → 183

BMF; Bcl-2-modifying factor, apoptosis