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H1f8 H1.8 linker histone [ Mus musculus (house mouse) ]

Gene ID: 171506, updated on 18-Apr-2024

Summary

Official Symbol
H1f8provided by MGI
Official Full Name
H1.8 linker histoneprovided by MGI
Primary source
MGI:MGI:2176207
See related
Ensembl:ENSMUSG00000042279 AllianceGenome:MGI:2176207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H1-8; H1.8; H1fo; H1oo; H1foo
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]
Expression
Restricted expression toward ovary adult (RPKM 8.4) See more
Orthologs
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Genomic context

Location:
6 E3; 6 53.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115921892..115927203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115944931..115950242)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115803828-115803937 Neighboring gene methyl-CpG binding domain protein 4 Neighboring gene intraflagellar transport 122 Neighboring gene STARR-positive B cell enhancer mm9_chr6:115895647-115895947 Neighboring gene rhodopsin Neighboring gene rhodopsin enhancer region Neighboring gene plexin D1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115921305-115921458 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115938993-115939194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115939698-115939944 Neighboring gene predicted gene, 53336

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosomal DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nucleosome assembly ISA
Inferred from Sequence Alignment
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in female germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H1.8
Names
H1 histone family, member O, oocyte-specific
histone H1oo
oocyte-specific histone H1
oocyte-specific linker histone H1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346702.1NP_001333631.1  histone H1.8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC142099, AK162154, DV655349
    Consensus CDS
    CCDS85133.1
    UniProtKB/TrEMBL
    E0CZ52
    Related
    ENSMUSP00000123797.2, ENSMUST00000161969.4
  2. NM_138311.3NP_612184.1  histone H1.8 isoform 1

    See identical proteins and their annotated locations for NP_612184.1

    Status: REVIEWED

    Source sequence(s)
    AK135944, AV357657, CJ081178
    Consensus CDS
    CCDS20447.1
    UniProtKB/Swiss-Prot
    Q8VIK3
    UniProtKB/TrEMBL
    E0CZ52
    Related
    ENSMUSP00000036951.8, ENSMUST00000037831.14
    Conserved Domains (1) summary
    cd00073
    Location:43134
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    115921892..115927203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)