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Camk1 calcium/calmodulin-dependent protein kinase I [ Rattus norvegicus (Norway rat) ]

Gene ID: 171503, updated on 18-Apr-2019

Summary

Official Symbol
Camk1provided by RGD
Official Full Name
calcium/calmodulin-dependent protein kinase Iprovided by RGD
Primary source
RGD:629473
See related
Ensembl:ENSRNOG00000021781
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gaip; Camki
Summary
activated by NMDA receptor induction and by glutamate; depolarization-induced activation is inhibited by nifedipine [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Heart (RPKM 146.8), Lung (RPKM 142.3) and 9 other tissues See more
Orthologs

Genomic context

See Camk1 in Genome Data Viewer
Location:
4q42
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145289300..145300146, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (208586449..208597283, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 14 Neighboring gene copine family member 9 Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) Neighboring gene cDNA sequence BC006662-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein acetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of synapse structural plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of syncytium formation by plasma membrane fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of syncytium formation by plasma membrane fusion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT regulation of histone H3-K9 acetylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synapse organization EXP
Inferred from Experiment
more info
PubMed 
regulation of synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type 1
Names
G alpha interacting protein
caM kinase I alpha
caM-KI
caMKI-alpha
regulator of G-protein signalling 19
NP_604463.1
XP_006237061.1
XP_006237062.1
XP_006237063.1
XP_006237064.1
XP_006237065.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134468.1NP_604463.1  calcium/calmodulin-dependent protein kinase type 1

    See identical proteins and their annotated locations for NP_604463.1

    Status: PROVISIONAL

    Source sequence(s)
    L26288
    UniProtKB/Swiss-Prot
    Q63450
    Conserved Domains (2) summary
    smart00220
    Location:20276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14167
    Location:16278
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    145289300..145300146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237002.3XP_006237064.1  calcium/calmodulin-dependent protein kinase type 1 isoform X3

    See identical proteins and their annotated locations for XP_006237064.1

    Conserved Domains (2) summary
    smart00220
    Location:20276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14167
    Location:16278
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha
  2. XM_006236999.2XP_006237061.1  calcium/calmodulin-dependent protein kinase type 1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:51307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14167
    Location:47309
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha
  3. XM_006237001.3XP_006237063.1  calcium/calmodulin-dependent protein kinase type 1 isoform X3

    See identical proteins and their annotated locations for XP_006237063.1

    Conserved Domains (2) summary
    smart00220
    Location:20276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14167
    Location:16278
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha
  4. XM_006237003.3XP_006237065.1  calcium/calmodulin-dependent protein kinase type 1 isoform X4

    See identical proteins and their annotated locations for XP_006237065.1

    UniProtKB/Swiss-Prot
    Q63450
    Related
    ENSRNOP00000033456.4, ENSRNOT00000029728.5
    Conserved Domains (2) summary
    smart00220
    Location:20276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14167
    Location:16278
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha
  5. XM_006237000.3XP_006237062.1  calcium/calmodulin-dependent protein kinase type 1 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:51307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14167
    Location:47309
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    135038512..135048763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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