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Cep170 centrosomal protein 170 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171457, updated on 30-Jul-2025
Symbol
Cep170provided by RGD
Full Name
centrosomal protein 170provided by RGD
Primary source
RGD:621868
See related
Ensembl:ENSRNOG00000004127 AllianceGenome:RGD:621868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kab; KAB1; Rhk1
Summary
Predicted to be located in centrosome; ciliary basal body; and cytosol. Predicted to be part of centriolar subdistal appendage. Predicted to be active in centriole. Orthologous to human CEP170 (centrosomal protein 170). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 252.9), Thymus (RPKM 183.4) and 9 other tissues See more
Orthologs
human mouse all
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See Cep170 in Genome Data Viewer
Location:
13q24
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (91201808..91285990, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (88669672..88754011, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (94807090..94887448, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene beclin 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phospholipase D family, member 5 Neighboring gene microRNA 350 Neighboring gene SHH signaling and ciliogenesis regulator SDCCAG8 Neighboring gene uncharacterized LOC134481601 Neighboring gene AKT serine/threonine kinase 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Molecular cloning and characterization of rKAB1, which interacts with KARP-1, localizes in the nucleus and protects cells against oxidative death. Do E, et al. Mol Cell Biochem, 2003 Jun. PMID 12870657
  2. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. Kodani A, et al. EMBO J, 2013 Feb 20. PMID 23386061, Free PMC Article
  3. 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Sonnen KF, et al. Biol Open, 2012 Oct 15. PMID 23213374, Free PMC Article
  4. A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Nechipurenko IV, et al. Dev Cell, 2016 Sep 12. PMID 27623382, Free PMC Article
  5. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. molecular cloning; localized in cell nucleus and in the condensed chromosome during the mitotic cell division; works as a protective protein against cell damage by oxidative stress
    Title: Molecular cloning and characterization of rKAB1, which interacts with KARP-1, localizes in the nucleus and protects cells against oxidative death.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
centrosomal protein of 170 kDa
Names
KARP-1 binding protein 1
centrosomal protein 170kDa
centrosomal protein of 170 kDa-like

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427216.1 → NP_001414145.1  centrosomal protein of 170 kDa

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JGC3
    Related
    ENSRNOP00000005532.6, ENSRNOT00000005532.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    91201808..91285990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272008.1 → XP_063128078.1  centrosomal protein of 170 kDa isoform X16

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

  2. XM_063272007.1 → XP_063128077.1  centrosomal protein of 170 kDa isoform X15

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

  3. XM_063272006.1 → XP_063128076.1  centrosomal protein of 170 kDa isoform X14

    UniProtKB/TrEMBL
    A6JGC3

  4. XM_063272005.1 → XP_063128075.1  centrosomal protein of 170 kDa isoform X13

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

  5. XM_063272004.1 → XP_063128074.1  centrosomal protein of 170 kDa isoform X12

    UniProtKB/TrEMBL
    A6JGC3

  6. XM_063272003.1 → XP_063128073.1  centrosomal protein of 170 kDa isoform X11

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

  7. XM_063272002.1 → XP_063128072.1  centrosomal protein of 170 kDa isoform X10

    UniProtKB/TrEMBL
    A6JGC3

  8. XM_063272000.1 → XP_063128070.1  centrosomal protein of 170 kDa isoform X8

    UniProtKB/TrEMBL
    A6JGC3

  9. XM_063271999.1 → XP_063128069.1  centrosomal protein of 170 kDa isoform X7

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5, D3ZET9, F1LNI7

  10. XM_063272001.1 → XP_063128071.1  centrosomal protein of 170 kDa isoform X9

    UniProtKB/TrEMBL
    A6JGC3

  11. XM_063271998.1 → XP_063128068.1  centrosomal protein of 170 kDa isoform X6

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

  12. XM_063271997.1 → XP_063128067.1  centrosomal protein of 170 kDa isoform X5

    UniProtKB/TrEMBL
    A6JGC3

  13. XM_063271996.1 → XP_063128066.1  centrosomal protein of 170 kDa isoform X4

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

  14. XM_063271995.1 → XP_063128065.1  centrosomal protein of 170 kDa isoform X3

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

  15. XM_063271994.1 → XP_063128064.1  centrosomal protein of 170 kDa isoform X2

    UniProtKB/TrEMBL
    A6JGC3

  16. XM_063271993.1 → XP_063128063.1  centrosomal protein of 170 kDa isoform X1

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5
    Related
    ENSRNOP00000072465.3, ENSRNOT00000079763.3

  17. XM_063272009.1 → XP_063128079.1  centrosomal protein of 170 kDa isoform X17

    UniProtKB/TrEMBL
    A0A0G2K315, A6JGC5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_134416.1: Suppressed sequence

    Description
    NM_134416.1: This RefSeq was temporarily suppressed because there were several mismatches, insertions, and deletions compared to available sequence data. These differences resulted in a protein that was truncated at both ends and
Nucleotide Protein Strain
Heading Accession and Version

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