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Adgrl2 adhesion G protein-coupled receptor L2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171447, updated on 17-Nov-2020

Summary

Official Symbol
Adgrl2provided by RGD
Official Full Name
adhesion G protein-coupled receptor L2provided by RGD
Primary source
RGD:620835
See related
Ensembl:ENSRNOG00000032660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cirl2; Cl2ac; Lphn2; Cirl-2
Summary
low affinity G-protein-coupled receptor for alpha-latrotoxin [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Heart (RPKM 155.2), Liver (RPKM 125.0) and 9 other tissues See more
Orthologs

Genomic context

See Adgrl2 in Genome Data Viewer
Location:
2q45
Exon count:
25
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (258792838..258997145, complement)
106 current Rn_Celera (GCF_000002265.2) 2 AC_000070.1 (229647140..230280349, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (277462664..277666602, complement) , (273089566..273220878, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene esterase D/formylglutathione hydrolase Neighboring gene uncharacterized LOC108350145 Neighboring gene uncharacterized LOC103690134 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 Neighboring gene uncharacterized LOC108350218 Neighboring gene uncharacterized LOC108350219

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
synapse organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor L2
Names
calcium-independent alpha-latrotoxin receptor 2
calcium-independent alpha-latrotoxin receptor homolog 2
latrophilin-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190475.2NP_001177404.2  adhesion G protein-coupled receptor L2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177404.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081153, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88923
    Related
    ENSRNOP00000043979.4, ENSRNOT00000042256.5
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8491099
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191478
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  2. NM_001302208.1NP_001289137.1  adhesion G protein-coupled receptor L2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001289137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081151, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88923
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8491099
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191467
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  3. NM_001302209.1NP_001289138.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001289138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (4) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081150, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88923
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    COG1266
    Location:9171091
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8491084
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  4. NM_001302210.1NP_001289139.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001289139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons and has an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (5) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081148, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88923
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    COG1266
    Location:9171091
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8491084
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041452
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  5. NM_001302211.1NP_001289140.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001289140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (6) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081152, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88923
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8491099
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191435
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  6. NM_001302212.1NP_001289141.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

    See identical proteins and their annotated locations for NP_001289141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (7) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AA899882, AF063102, AF081149, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88923
    UniProtKB/TrEMBL
    D3ZNG0
    Related
    ENSRNOP00000041829.5, ENSRNOT00000045020.5
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    COG1266
    Location:9171091
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8491084
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041420
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  7. NM_134408.3NP_599235.3  adhesion G protein-coupled receptor L2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA899882, AF063102, AF081148, AF081151, CB579130, CO556290, FM039554, FM068641, FM099106
    UniProtKB/Swiss-Prot
    O88923
    Related
    ENSRNOP00000042136.4, ENSRNOT00000045905.5
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8491108
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11281487
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    258792838..258997145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    229647140..230280349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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