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Slc26a6 solute carrier family 26, member 6 [ Mus musculus (house mouse) ]

Gene ID: 171429, updated on 8-Dec-2022

Summary

Official Symbol
Slc26a6provided by MGI
Official Full Name
solute carrier family 26, member 6provided by MGI
Primary source
MGI:MGI:2159728
See related
Ensembl:ENSMUSG00000023259 AllianceGenome:MGI:2159728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CFEX; Pat1; Pat-1; B930010B04Rik
Summary
Enables PDZ domain binding activity and anion transmembrane transporter activity. Involved in several processes, including anion transport; cellular response to cAMP; and cellular response to fructose stimulus. Located in several cellular components, including apical plasma membrane; brush border membrane; and sperm midpiece. Is integral component of plasma membrane. Orthologous to human SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 132.0), small intestine adult (RPKM 106.4) and 2 other tissues See more
Orthologs
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Genomic context

See Slc26a6 in Genome Data Viewer
Location:
9; 9 F2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108731239..108742117)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108854043..108913049)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35025 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 3 Neighboring gene transmembrane protein 89 Neighboring gene ubiquinol-cytochrome c reductase core protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bicarbonate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables bicarbonate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chloride transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables formate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxalate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxalate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables solute:inorganic anion antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables solute:inorganic anion antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bicarbonate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bicarbonate transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within bicarbonate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicarbonate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fructose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial fluid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within formate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in formate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in formate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular pH elevation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mannitol transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in oxalate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxalate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oxalate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in oxalic acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dipeptide transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase C signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm capacitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sulfate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sulfate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transepithelial chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transepithelial chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier family 26 member 6
Names
anion exchange transporter
chloride-formate exchanger
pendrin-L1
pendrin-like protein 1
putative anion transporter-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408387.1NP_001395316.1  solute carrier family 26 member 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC168054, AEKQ02060806
    UniProtKB/Swiss-Prot
    Q923J3
  2. NM_134420.5NP_599252.2  solute carrier family 26 member 6 isoform 1

    See identical proteins and their annotated locations for NP_599252.2

    Status: VALIDATED

    Source sequence(s)
    AC168054, AEKQ02060806
    UniProtKB/Swiss-Prot
    Q8CIW6
    Related
    ENSMUSP00000159445.2, ENSMUST00000239562.1
    Conserved Domains (1) summary
    TIGR00815
    Location:55714
    sulP; high affinity sulphate transporter 1

RNA

  1. NR_176680.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC168054, AEKQ02060806

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108731239..108742117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154634.1XP_036010527.1  solute carrier family 26 member 6 isoform X2

    Conserved Domains (1) summary
    TIGR00815
    Location:55714
    sulP; high affinity sulphate transporter 1
  2. XM_036154633.1XP_036010526.1  solute carrier family 26 member 6 isoform X1

    Related
    ENSMUSP00000140849.3, ENSMUST00000188557.8
    Conserved Domains (1) summary
    TIGR00815
    Location:78737
    sulP; high affinity sulphate transporter 1