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Slc22a27 solute carrier family 22, member 27 [ Mus musculus (house mouse) ]

Gene ID: 171405, updated on 8-Feb-2024

Summary

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Official Symbol
Slc22a27provided by MGI
Official Full Name
solute carrier family 22, member 27provided by MGI
Primary source
MGI:MGI:3042283
See related
Ensembl:ENSMUSG00000067656 AllianceGenome:MGI:3042283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oat9; OAT6-L; OAT6-S
Summary
Predicted to enable anion:anion antiporter activity; short-chain fatty acid transmembrane transporter activity; and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; and lung. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25) and SLC22A9 (solute carrier family 22 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 10.2) and kidney adult (RPKM 4.4) See more
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Genomic context

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See Slc22a27 in Genome Data Viewer
Location:
19 A; 19 5.36 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7841753..7943899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7864388..7966517, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 26 Neighboring gene STARR-seq mESC enhancer starr_45473 Neighboring gene solute carrier family 22 (organic cation transporter), member 26 pseudogene Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene calpastatin pseudogene Neighboring gene solute carrier family 22, member 28 Neighboring gene STARR-seq mESC enhancer starr_45475

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney. Tsuchida H, et al. Cell Physiol Biochem, 2010. PMID 20332632
  2. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Wu W, et al. Physiol Genomics, 2009 Jul 9. PMID 19417012, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oat9S appears to be the first member to mediate the transport of carnitine and possesses eight transmembrane domains.
    Title: Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables short-chain fatty acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 27
Names
mOAT6 related protein
organic anion transporter 6
organic anion transporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361980.1 → NP_001348909.1  solute carrier family 22 member 27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115715, AC122119
    Consensus CDS
    CCDS89333.1
    Related
    ENSMUSP00000138475.2, ENSMUST00000182102.8
    Conserved Domains (1) summary
    cl26863
    Location:11 → 416
    Sugar_tr; Sugar (and other) transporter

  2. NM_134256.1 → NP_599017.1  solute carrier family 22 member 27 isoform 1

    See identical proteins and their annotated locations for NP_599017.1

    Status: VALIDATED

    Source sequence(s)
    AB056442
    Consensus CDS
    CCDS50380.1
    UniProtKB/Swiss-Prot
    Q76M71, Q76M72
    UniProtKB/TrEMBL
    Q687I4
    Related
    ENSMUSP00000093991.2, ENSMUST00000075619.5
    Conserved Domains (1) summary
    cd17374
    Location:109 → 515
    MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7841753..7943899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526728.3 → XP_006526791.1  solute carrier family 22 member 27 isoform X2

    See identical proteins and their annotated locations for XP_006526791.1

    UniProtKB/Swiss-Prot
    Q76M71, Q76M72
    UniProtKB/TrEMBL
    Q687I4
    Conserved Domains (1) summary
    cd17374
    Location:109 → 515
    MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

  2. XM_017318076.3 → XP_017173565.1  solute carrier family 22 member 27 isoform X1

    UniProtKB/TrEMBL
    Q687I4
    Conserved Domains (1) summary
    cd17374
    Location:134 → 540
    MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

  3. XM_017318077.3 → XP_017173566.1  solute carrier family 22 member 27 isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:137 → 307
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76M72.1 GenPept UniProtKB/Swiss-Prot:Q76M72

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