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Trpm8 transient receptor potential cation channel, subfamily M, member 8 [ Mus musculus (house mouse) ]

Gene ID: 171382, updated on 5-Jan-2023

Summary

Official Symbol
Trpm8provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 8provided by MGI
Primary source
MGI:MGI:2181435
See related
Ensembl:ENSMUSG00000036251 AllianceGenome:MGI:2181435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CMR1; TRPP8; LTRPC6; Trp-p8; LTrpC-6
Summary
Enables calcium channel activity and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in external side of plasma membrane. Is expressed in dorsal root ganglion; inferior vagus ganglion; and vagus ganglion. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.5), CNS E18 (RPKM 0.2) and 1 other tissue See more
Orthologs
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Genomic context

See Trpm8 in Genome Data Viewer
Location:
1; 1 D
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88234457..88316575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88306735..88388853)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene secreted phosphoprotein 2 Neighboring gene predicted gene 29538 Neighboring gene predicted gene 28888

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2849

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ligand-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to cold IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cold ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to temperature stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thermoception IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within thermoception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 8
Names
TRP ion channel TRPM8
long transient receptor potential channel 6
transient receptor potential p8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134252.5NP_599013.1  transient receptor potential cation channel subfamily M member 8

    See identical proteins and their annotated locations for NP_599013.1

    Status: VALIDATED

    Source sequence(s)
    AC087780, AC102505, FQ976922
    Consensus CDS
    CCDS48316.1
    UniProtKB/Swiss-Prot
    Q148W9, Q8R4D5
    Related
    ENSMUSP00000108739.4, ENSMUST00000113114.10
    Conserved Domains (2) summary
    TIGR00870
    Location:6571005
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:116386
    LSDAT_euk; SLOG in TRPM

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    88234457..88316575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529226.2XP_006529289.1  transient receptor potential cation channel subfamily M member 8 isoform X1

    See identical proteins and their annotated locations for XP_006529289.1

    UniProtKB/Swiss-Prot
    Q148W9, Q8R4D5
    Related
    ENSMUSP00000036991.8, ENSMUST00000040210.14
    Conserved Domains (2) summary
    TIGR00870
    Location:6571005
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:116386
    LSDAT_euk; SLOG in TRPM
  2. XM_017319118.2XP_017174607.1  transient receptor potential cation channel subfamily M member 8 isoform X2

    Conserved Domains (1) summary
    cl39032
    Location:116386
    LSDAT_euk; SLOG in TRPM
  3. XM_006529225.2XP_006529288.1  transient receptor potential cation channel subfamily M member 8 isoform X1

    See identical proteins and their annotated locations for XP_006529288.1

    UniProtKB/Swiss-Prot
    Q148W9, Q8R4D5
    Related
    ENSMUSP00000131209.3, ENSMUST00000171176.3
    Conserved Domains (2) summary
    TIGR00870
    Location:6571005
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:116386
    LSDAT_euk; SLOG in TRPM
  4. XM_006529229.1XP_006529292.1  transient receptor potential cation channel subfamily M member 8 isoform X3

    Conserved Domains (1) summary
    TIGR00870
    Location:148496
    trp; transient-receptor-potential calcium channel protein