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Havcr2 hepatitis A virus cellular receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 171285, updated on 29-Jan-2023

Summary

Official Symbol
Havcr2provided by MGI
Official Full Name
hepatitis A virus cellular receptor 2provided by MGI
Primary source
MGI:MGI:2159682
See related
Ensembl:ENSMUSG00000020399 AllianceGenome:MGI:2159682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim3; TIM-3; Timd3
Summary
Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dorsal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 1.3), lung adult (RPKM 0.8) and 22 other tissues See more
Orthologs
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Genomic context

See Havcr2 in Genome Data Viewer
Location:
11; 11 B1.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46345758..46372082)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46454931..46481255)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 7 Neighboring gene predicted gene 12168 Neighboring gene predicted gene 12169 Neighboring gene developmental pluripotency associated 1 family member pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124149, MGC124150

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maternal process involved in female pregnancy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maternal process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
 
involved_in natural killer cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of granulocyte colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immune response to tumor cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-3 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myeloid dendritic cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tolerance induction dependent upon immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 7 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hepatitis A virus cellular receptor 2 homolog
Names
HAVcr-2
T-cell immunoglobulin and mucin domain containing 3
T-cell immunoglobulin and mucin domain-containing protein 3
T-cell immunoglobulin mucin receptor 3
T-cell membrane protein 3
TIMD-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134250.2NP_599011.2  hepatitis A virus cellular receptor 2 homolog precursor

    See identical proteins and their annotated locations for NP_599011.2

    Status: VALIDATED

    Source sequence(s)
    AK148474, AL669948
    Consensus CDS
    CCDS36135.1
    UniProtKB/Swiss-Prot
    Q8VIM0
    Related
    ENSMUSP00000020668.9, ENSMUST00000020668.15
    Conserved Domains (2) summary
    smart00410
    Location:26112
    IG_like; Immunoglobulin like
    pfam07686
    Location:29117
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    46345758..46372082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)