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Timd2 T cell immunoglobulin and mucin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 171284, updated on 26-Sep-2022

Summary

Official Symbol
Timd2provided by MGI
Official Full Name
T cell immunoglobulin and mucin domain containing 2provided by MGI
Primary source
MGI:MGI:2159681
See related
Ensembl:ENSMUSG00000040413 AllianceGenome:MGI:2159681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G9D3; Tim2; TIM-2
Summary
Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 18.2), liver adult (RPKM 17.7) and 4 other tissues See more
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Genomic context

See Timd2 in Genome Data Viewer
Location:
11; 11 B1.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46559787..46597934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46668960..46707107, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 1 Neighboring gene T-cell immunoglobulin and mucin domain containing 2 pseudogene Neighboring gene predicted gene 12174 Neighboring gene hepatitis A virus cellular receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ferritin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables virus receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within iron ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mast cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-cell immunoglobulin and mucin domain-containing protein 2
Names
T-cell immunoglobulin mucin receptor 2
T-cell membrane protein 2
TIMD-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161355.1NP_001154827.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001154827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), variant 2 and variant 3 encode the same protein.
    Source sequence(s)
    AK145630, AK163225, AK166877, CB953226
    Consensus CDS
    CCDS24582.1
    UniProtKB/Swiss-Prot
    Q8R183
    UniProtKB/TrEMBL
    A8C1R4
    Related
    ENSMUSP00000104848.3, ENSMUST00000109225.9
    Conserved Domains (1) summary
    pfam07686
    Location:30119
    V-set; Immunoglobulin V-set domain
  2. NM_001161356.1NP_001154828.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001154828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AB009015, AK145630, AK166877
    Consensus CDS
    CCDS24582.1
    UniProtKB/Swiss-Prot
    Q8R183
    UniProtKB/TrEMBL
    A8C1R4
    Related
    ENSMUSP00000131540.2, ENSMUST00000169584.8
    Conserved Domains (1) summary
    pfam07686
    Location:30119
    V-set; Immunoglobulin V-set domain
  3. NM_134249.5NP_599010.4  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_599010.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK145630, AK163225, AK166877, BY731803
    Consensus CDS
    CCDS24582.1
    UniProtKB/Swiss-Prot
    Q8R183
    UniProtKB/TrEMBL
    A8C1R4
    Related
    ENSMUSP00000060891.7, ENSMUST00000055102.13
    Conserved Domains (1) summary
    pfam07686
    Location:30119
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    46559787..46597934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245625.1XP_030101485.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A8C1R4
    Conserved Domains (1) summary
    pfam07686
    Location:30119
    V-set; Immunoglobulin V-set domain
  2. XM_030245624.1XP_030101484.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A8C1R4
    Conserved Domains (1) summary
    pfam07686
    Location:30119
    V-set; Immunoglobulin V-set domain