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Acot3 acyl-CoA thioesterase 3 [ Mus musculus (house mouse) ]

Gene ID: 171281, updated on 24-Sep-2025
Official Symbol
Acot3provided by MGI
Official Full Name
acyl-CoA thioesterase 3provided by MGI
Primary source
MGI:MGI:2159619
See related
Ensembl:ENSMUSG00000021228 AllianceGenome:MGI:2159619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pte2a; PTE-Ia
Summary
Enables fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process and carboxylic acid metabolic process. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in liver adult (RPKM 11.8), kidney adult (RPKM 11.2) and 16 other tissues See more
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See Acot3 in Genome Data Viewer
Location:
12 D1; 12 39.02 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84098918..84107174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84052144..84060400)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene predicted gene, 40474 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 5 Neighboring gene acyl-CoA thioesterase 5 pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. Westin MA, et al. J Biol Chem, 2004 May 21. PMID 15007068
  2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
  3. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. Hunt MC, et al. J Biol Chem, 1999 Nov 26. PMID 10567408
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in saturated monocarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in unsaturated monocarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
acyl-coenzyme A thioesterase 3
Names
peroxisomal acyl-CoA thioesterase 2A
peroxisomal acyl-coenzyme A thioester hydrolase 2a
peroxisomal long-chain acyl-CoA thioesterase 2
NP_001333630.1
NP_599007.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346701.1 → NP_001333630.1  acyl-coenzyme A thioesterase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133183
    Consensus CDS
    CCDS83985.1
    Related
    ENSMUSP00000112678.2, ENSMUST00000120927.8

  2. NM_134246.3 → NP_599007.1  acyl-coenzyme A thioesterase 3 isoform 1

    See identical proteins and their annotated locations for NP_599007.1

    Status: VALIDATED

    Source sequence(s)
    AC133183
    Consensus CDS
    CCDS26036.1
    UniProtKB/Swiss-Prot
    Q6Q2Z7, Q9QYR7
    UniProtKB/TrEMBL
    Q53YL1
    Related
    ENSMUSP00000021653.7, ENSMUST00000021653.8
    Conserved Domains (3) summary
    pfam04775
    Location:28 → 148
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:214 → 423
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    cl21494
    Location:148 → 264
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84098918..84107174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYR7.1 GenPept UniProtKB/Swiss-Prot:Q9QYR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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