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Smad2 SMAD family member 2 [ Mus musculus (house mouse) ]

Gene ID: 17126, updated on 13-Jan-2020

Summary

Official Symbol
Smad2provided by MGI
Official Full Name
SMAD family member 2provided by MGI
Primary source
MGI:MGI:108051
See related
Ensembl:ENSMUSG00000024563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Madh2; Madr2; mMad2; Smad-2; 7120426M23Rik
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 7.1), bladder adult (RPKM 6.8) and 28 other tissues See more
Orthologs

Genomic context

See Smad2 in Genome Data Viewer
Location:
18 E3; 18 51.42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (76241090..76311748)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (76401579..76465385)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 52360 Neighboring gene predicted gene 9028 Neighboring gene predicted gene, 41778 Neighboring gene predicted gene, 41779 Neighboring gene predicted gene, 31875

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IPI
Inferred from Physical Interaction
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
primary miRNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
tau protein binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO
Inferred from Sequence Orthology
more info
 
type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adrenal gland development ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
common-partner SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
developmental growth IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic foregut morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
endoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
endoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
nodal signaling pathway ISO
Inferred from Sequence Orthology
more info
 
organ growth IGI
Inferred from Genetic Interaction
more info
PubMed 
pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
paraxial mesoderm morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
pericardium development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
response to glucose IGI
Inferred from Genetic Interaction
more info
PubMed 
secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
zygotic specification of dorsal/ventral axis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
activin responsive factor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
heteromeric SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 2
Names
MAD homolog 2
Smad 2
mad-related protein 2
mothers against DPP homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252481.1NP_001239410.1  mothers against decapentaplegic homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001239410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC164009
    Consensus CDS
    CCDS29350.1
    UniProtKB/Swiss-Prot
    Q62432
    Related
    ENSMUSP00000025453.8, ENSMUST00000025453.14
    Conserved Domains (2) summary
    cd10491
    Location:8172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
  2. NM_001311070.1NP_001297999.1  mothers against decapentaplegic homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001297999.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a shorter 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC164009, AK007817, AK078612, AY334552, BC058713, BM248478
    Consensus CDS
    CCDS79664.1
    UniProtKB/Swiss-Prot
    Q62432
    Related
    ENSMUSP00000109563.2, ENSMUST00000113930.2
    Conserved Domains (2) summary
    cd10491
    Location:8142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
  3. NM_010754.5NP_034884.2  mothers against decapentaplegic homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_034884.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC164009, AK007817, BC058713, BM248478, BU058005, CN456711
    Consensus CDS
    CCDS29350.1
    UniProtKB/Swiss-Prot
    Q62432
    Related
    ENSMUSP00000130115.1, ENSMUST00000168423.8
    Conserved Domains (2) summary
    cd10491
    Location:8172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p6 C57BL/6J

    Range
    76241090..76311748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317842.2XP_017173331.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/Swiss-Prot
    Q62432
    Related
    ENSMUSP00000089439.6, ENSMUST00000091831.12
    Conserved Domains (2) summary
    cd10491
    Location:8142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
  2. XM_030250351.1XP_030106211.1  mothers against decapentaplegic homolog 2 isoform X2

  3. XM_006525699.3XP_006525762.1  mothers against decapentaplegic homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006525762.1

    UniProtKB/Swiss-Prot
    Q62432
    Conserved Domains (2) summary
    cd10491
    Location:8172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
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