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UBE2L5 ubiquitin conjugating enzyme E2 L5 [ Homo sapiens (human) ]

Gene ID: 171222, updated on 5-Aug-2022

Summary

Official Symbol
UBE2L5provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 L5provided by HGNC
Primary source
HGNC:HGNC:13477
See related
Ensembl:ENSG00000236444 AllianceGenome:HGNC:13477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBCH7N2; UBE2L5P
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein K11-linked ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See UBE2L5 in Genome Data Viewer
Location:
13q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (30422493..30429758)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (29644906..29652176)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (30996630..31003895)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903145 Neighboring gene long intergenic non-protein coding RNA 426 Neighboring gene long intergenic non-protein coding RNA 1058 Neighboring gene uncharacterized LOC107984577 Neighboring gene high mobility group box 1 Neighboring gene RNA binding motif protein 22 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 L5
Names
ubiquitin-protein ligase L5
NP_001342176.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355247.2NP_001342176.1  ubiquitin-conjugating enzyme E2 L5

    Status: VALIDATED

    Source sequence(s)
    AL161893
    Consensus CDS
    CCDS86346.1
    UniProtKB/Swiss-Prot
    A0A1B0GUS4
    Related
    ENSP00000490225.1, ENST00000635918.2
    Conserved Domains (1) summary
    smart00212
    Location:6149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    30422493..30429758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    29644906..29652176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_001319.3: Suppressed sequence

    Description
    NG_001319.3: This RefSeq was removed because it is now thought that this locus is a transcribed gene.