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Acot2 acyl-CoA thioesterase 2 [ Mus musculus (house mouse) ]

Gene ID: 171210, updated on 27-Feb-2024

Summary

Official Symbol
Acot2provided by MGI
Official Full Name
acyl-CoA thioesterase 2provided by MGI
Primary source
MGI:MGI:2159605
See related
Ensembl:ENSMUSG00000021226 AllianceGenome:MGI:2159605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mte1; MTE-I
Summary
Predicted to enable palmitoyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process; fatty acid metabolic process; and response to hypoxia. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 20.3), heart adult (RPKM 16.9) and 27 other tissues See more
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Genomic context

See Acot2 in Genome Data Viewer
Location:
12 D1; 12 38.99 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84034635..84040651)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83987861..83993877)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene NUMB endocytic adaptor protein Neighboring gene STARR-positive B cell enhancer ABC_E474 Neighboring gene predicted gene, 31386 Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_32720 Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene predicted gene, 40474 Neighboring gene acyl-CoA thioesterase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within acyl-CoA metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in very long-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 2, mitochondrial
Names
acyl coenzyme A thioester hydrolase
mitochondrial acyl-CoA thioesterase 1
very-long-chain acyl-CoA thioesterase
NP_598949.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134188.3NP_598949.3  acyl-coenzyme A thioesterase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_598949.3

    Status: VALIDATED

    Source sequence(s)
    AC133183, AK141651, BC064469
    Consensus CDS
    CCDS26034.1
    UniProtKB/Swiss-Prot
    Q3T9C9, Q9QYR9
    UniProtKB/TrEMBL
    Q6P2K2
    Related
    ENSMUSP00000021649.8, ENSMUST00000021649.8
    Conserved Domains (3) summary
    pfam04775
    Location:58178
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:244451
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    cl21494
    Location:186298
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84034635..84040651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)