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Mxd3 Max dimerization protein 3 [ Mus musculus (house mouse) ]

Gene ID: 17121, updated on 26-Sep-2022

Summary

Official Symbol
Mxd3provided by MGI
Official Full Name
Max dimerization protein 3provided by MGI
Primary source
MGI:MGI:104987
See related
Ensembl:ENSMUSG00000021485 AllianceGenome:MGI:104987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mad3; bHLHc13; 4631412E13Rik
Summary
Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription, DNA-templated. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; limb mesenchyme; retina; and thymus. Orthologous to human MXD3 (MAX dimerization protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 35.6), duodenum adult (RPKM 33.9) and 24 other tissues See more
Orthologs
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Genomic context

See Mxd3 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55472983..55477937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55325170..55329900, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor-binding SET-domain protein 1 Neighboring gene PRELI domain containing 1 Neighboring gene RAB24, member RAS oncogene family Neighboring gene lectin, mannose-binding 2 Neighboring gene regulator of G-protein signaling 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
max dimerization protein 3
Names
max dimerizer 3
max-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016662.5NP_057871.2  max dimerization protein 3

    See identical proteins and their annotated locations for NP_057871.2

    Status: VALIDATED

    Source sequence(s)
    AK138742, BC051970
    Consensus CDS
    CCDS26543.1
    UniProtKB/Swiss-Prot
    Q60947, Q80US8
    Related
    ENSMUSP00000021941.8, ENSMUST00000021941.8
    Conserved Domains (1) summary
    smart00353
    Location:63115
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55472983..55477937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_873434.4 RNA Sequence