Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adh7provided by RGD
Official Full Name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideprovided by RGD
Primary source: RGD:621638
See related: Ensembl:ENSRNOG00000032959 AllianceGenome:RGD:621638
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including NAD binding activity; alcohol binding activity; and zinc ion binding activity. Involved in ethanol metabolic process and retinol metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 91.3) and Lung (RPKM 19.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229422125..229436584)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226748724..226763183)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243500540..243516865)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NO generation from nitrite mainly occurs in tissues not in the blood, with XO and AO playing critical roles in nitrite reduction, and this process is regulated by pH, oxygen tension, nitrite, and reducing substrate concentrations
Title: Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity	TAS Traceable Author Statement more info	PubMed
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent	ISO Inferred from Sequence Orthology more info
enables aldehyde oxidase activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ethanol binding	IDA Inferred from Direct Assay more info	PubMed
enables ethanol binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables omega-hydroxydecanoate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables retinol binding	IDA Inferred from Direct Assay more info	PubMed
enables retinol binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ethanol catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ethanol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ethanol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid omega-oxidation	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinol metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: all-trans-retinol dehydrogenase [NAD(+)] ADH7

Names: alcohol dehydrogenase class 4 mu/sigma chain; alcohol dehydrogenase class IV mu/sigma chain; class IV alcohol dehydrogenase, mu or sigma subunit; omega-hydroxydecanoate dehydrogenase ADH7

NP_599156.2

EC 1.1.1.1

EC 1.1.1.105

EC 1.1.1.66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134329.2 → NP_599156.2 all-trans-retinol dehydrogenase [NAD(+)] ADH7

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O55146, P41682

UniProtKB/TrEMBL

A6HW25

Related

ENSRNOP00000015870.5, ENSRNOT00000015870.5

Conserved Domains (1) summary

cd08299
Location:3 → 374

alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases