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RHOV ras homolog family member V [ Homo sapiens (human) ]

Gene ID: 171177, updated on 22-Aug-2020

Summary

Official Symbol
RHOVprovided by HGNC
Official Full Name
ras homolog family member Vprovided by HGNC
Primary source
HGNC:HGNC:18313
See related
Ensembl:ENSG00000104140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHP; ARHV; WRCH2
Expression
Biased expression in esophagus (RPKM 34.6), skin (RPKM 27.2) and 5 other tissues See more
Orthologs

Genomic context

See RHOV in Genome Data Viewer
Location:
15q15.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40872214..40874234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41164412..41166487, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene SPINT1 antisense RNA 1 Neighboring gene serine peptidase inhibitor, Kunitz type 1 Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC105370943

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoV
Names
CDC42-like GTPase 2
GTP-binding protein-like 2
Rho GTPase-like protein ARHV
WRCH-2
WRCH1-related GTPase
Wnt-1 regulated Cdc42 homolog 2
Wnt-1 responsive Cdc42 homolog 2
ras homolog gene family, member V

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133639.4NP_598378.3  rho-related GTP-binding protein RhoV

    See identical proteins and their annotated locations for NP_598378.3

    Status: VALIDATED

    Source sequence(s)
    AC025166, BC112945
    Consensus CDS
    CCDS10068.1
    UniProtKB/Swiss-Prot
    Q96L33
    UniProtKB/TrEMBL
    A0A024R9R2
    Related
    ENSP00000220507.4, ENST00000220507.5
    Conserved Domains (1) summary
    cd04130
    Location:32205
    Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    40872214..40874234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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