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RHOV ras homolog family member V [ Homo sapiens (human) ]

Gene ID: 171177, updated on 18-Sep-2024

Summary

Official Symbol
RHOVprovided by HGNC
Official Full Name
ras homolog family member Vprovided by HGNC
Primary source
HGNC:HGNC:18313
See related
Ensembl:ENSG00000104140 MIM:620101; AllianceGenome:HGNC:18313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHP; ARHV; WRCH2
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; cell projection assembly; and endocytosis. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 34.6), skin (RPKM 27.2) and 5 other tissues See more
Orthologs
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Genomic context

See RHOV in Genome Data Viewer
Location:
15q15.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40872214..40874234, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38678234..38680254, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41164412..41166432, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41117412-41117912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41117913-41118413 Neighboring gene Sharpr-MPRA regulatory region 7770 Neighboring gene SPINT1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41135684-41135866 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41135819-41136390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6344 Neighboring gene serine peptidase inhibitor, Kunitz type 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9268 Neighboring gene uncharacterized LOC124903475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9270 Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene Sharpr-MPRA regulatory region 6315 Neighboring gene uncharacterized LOC105370943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9271

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoV
Names
CDC42-like GTPase 2
GTP-binding protein-like 2
Rho GTPase-like protein ARHV
WRCH-2
WRCH1-related GTPase
Wnt-1 regulated Cdc42 homolog 2
Wnt-1 responsive Cdc42 homolog 2
ras homolog gene family, member V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133639.4NP_598378.3  rho-related GTP-binding protein RhoV

    See identical proteins and their annotated locations for NP_598378.3

    Status: VALIDATED

    Source sequence(s)
    AC025166, BC112945
    Consensus CDS
    CCDS10068.1
    UniProtKB/Swiss-Prot
    Q2KHQ5, Q8TDW6, Q96L33
    UniProtKB/TrEMBL
    Q05D03
    Related
    ENSP00000220507.4, ENST00000220507.5
    Conserved Domains (1) summary
    cd04130
    Location:32205
    Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40872214..40874234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    38678234..38680254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)