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Mcoln3 mucolipin 3 [ Mus musculus (house mouse) ]

Gene ID: 171166, updated on 12-Aug-2018

Summary

Official Symbol
Mcoln3provided by MGI
Official Full Name
mucolipin 3provided by MGI
Primary source
MGI:MGI:1890500
See related
Ensembl:ENSMUSG00000036853 Vega:OTTMUSG00000026569
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Va; TRPML3; 6720490O21Rik
Expression
Biased expression in placenta adult (RPKM 3.2), kidney adult (RPKM 2.7) and 9 other tissues See more
Orthologs

Genomic context

See Mcoln3 in Genome Data Viewer
Location:
3 H2; 3 71.03 cM
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (146093277..146141808)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (145784755..145803610)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene synapse defective 1, Rho GTPase, homolog 2 (C. elegans) Neighboring gene predicted gene, 40166 Neighboring gene predicted gene, 35409 Neighboring gene WD repeat domain 63 Neighboring gene mucolipin 2 Neighboring gene lysophosphatidic acid receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC124245, MGC124246

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAADP-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cation channel activity IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mucolipin-3
Names
transient receptor potential channel mucolipin 3
varitint-waddler

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134160.1NP_598921.1  mucolipin-3

    See identical proteins and their annotated locations for NP_598921.1

    Status: PROVISIONAL

    Source sequence(s)
    AF475086
    Consensus CDS
    CCDS17900.1
    UniProtKB/Swiss-Prot
    Q8R4F0
    UniProtKB/TrEMBL
    Q3KP78
    Related
    ENSMUSP00000038801.4, OTTMUSP00000032798, ENSMUST00000039450.4, OTTMUST00000065733
    Conserved Domains (1) summary
    pfam08016
    Location:343508
    PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    146093277..146141808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501083.3XP_006501146.1  mucolipin-3 isoform X1

    See identical proteins and their annotated locations for XP_006501146.1

    UniProtKB/Swiss-Prot
    Q8R4F0
    UniProtKB/TrEMBL
    Q3KP78
    Conserved Domains (1) summary
    pfam08016
    Location:343508
    PKD_channel; Polycystin cation channel
  2. XM_006501084.3XP_006501147.1  mucolipin-3 isoform X1

    See identical proteins and their annotated locations for XP_006501147.1

    UniProtKB/Swiss-Prot
    Q8R4F0
    UniProtKB/TrEMBL
    Q3KP78
    Conserved Domains (1) summary
    pfam08016
    Location:343508
    PKD_channel; Polycystin cation channel
  3. XM_006501087.3XP_006501150.1  mucolipin-3 isoform X3

    See identical proteins and their annotated locations for XP_006501150.1

    Conserved Domains (1) summary
    pfam08016
    Location:258423
    PKD_channel; Polycystin cation channel
  4. XM_006501082.3XP_006501145.1  mucolipin-3 isoform X1

    See identical proteins and their annotated locations for XP_006501145.1

    UniProtKB/Swiss-Prot
    Q8R4F0
    UniProtKB/TrEMBL
    Q3KP78
    Conserved Domains (1) summary
    pfam08016
    Location:343508
    PKD_channel; Polycystin cation channel
  5. XM_006501081.2XP_006501144.1  mucolipin-3 isoform X1

    See identical proteins and their annotated locations for XP_006501144.1

    UniProtKB/Swiss-Prot
    Q8R4F0
    UniProtKB/TrEMBL
    Q3KP78
    Conserved Domains (1) summary
    pfam08016
    Location:343508
    PKD_channel; Polycystin cation channel
  6. XM_006501085.2XP_006501148.1  mucolipin-3 isoform X2

    Conserved Domains (1) summary
    pfam08016
    Location:343439
    PKD_channel; Polycystin cation channel
  7. XM_006501086.3XP_006501149.1  mucolipin-3 isoform X3

    See identical proteins and their annotated locations for XP_006501149.1

    Conserved Domains (1) summary
    pfam08016
    Location:258423
    PKD_channel; Polycystin cation channel
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