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Slc6a5 solute carrier family 6 member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171148, updated on 2-Oct-2018

Summary

Official Symbol
Slc6a5provided by RGD
Official Full Name
solute carrier family 6 member 5provided by RGD
Primary source
RGD:621824
See related
Ensembl:ENSRNOG00000031662
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GLYT2
Summary
glycine transporter [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 649.2) See more
Orthologs

Genomic context

See Slc6a5 in Genome Data Viewer
Location:
1q22
Exon count:
18
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (105270418..105336369)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (106333982..106385232)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene HIV-1 Tat interactive protein 2 Neighboring gene protein arginine methyltransferase 3 Neighboring gene neural EGFL like 1 Neighboring gene 60S ribosomal protein L31-like Neighboring gene hypothetical protein LOC100125384

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
glycine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
glycine:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
glycine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
glycine transport IDA
Inferred from Direct Assay
more info
PubMed 
neurotransmitter reuptake ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter uptake EXP
Inferred from Experiment
more info
PubMed 
synaptic transmission, glycinergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic transmission, glycinergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
glycinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium- and chloride-dependent glycine transporter 2
Names
glyT-2
glycine transporter 2
solute carrier family 6 (neurotransmitter transporter), member 5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203334.1NP_976079.1  sodium- and chloride-dependent glycine transporter 2

    See identical proteins and their annotated locations for NP_976079.1

    Status: PROVISIONAL

    Source sequence(s)
    L21672
    UniProtKB/Swiss-Prot
    P58295
    Related
    ENSRNOP00000043665.4, ENSRNOT00000041950.4
    Conserved Domains (1) summary
    cd11499
    Location:193789
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    105270418..105336369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588729.1XP_017444218.1  sodium- and chloride-dependent glycine transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    P58295
    Related
    ENSRNOP00000074102.1, ENSRNOT00000089693.1
  2. XM_017588733.1XP_017444222.1  sodium- and chloride-dependent glycine transporter 2 isoform X4

  3. XM_008759310.1XP_008757532.1  sodium- and chloride-dependent glycine transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_008757532.1

    Conserved Domains (1) summary
    cd11499
    Location:206802
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain
  4. XM_017588730.1XP_017444219.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

  5. XM_017588732.1XP_017444221.1  sodium- and chloride-dependent glycine transporter 2 isoform X4

  6. XM_017588731.1XP_017444220.1  sodium- and chloride-dependent glycine transporter 2 isoform X4

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    93839503..93890460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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