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Ap3m1 adaptor related protein complex 3 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171126, updated on 5-Sep-2025
Official Symbol
Ap3m1provided by RGD
Official Full Name
adaptor related protein complex 3 subunit mu 1provided by RGD
Primary source
RGD:620417
See related
Ensembl:ENSRNOG00000011461 AllianceGenome:RGD:620417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P47a
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in anterograde synaptic vesicle transport and postsynaptic neurotransmitter receptor internalization. Predicted to be located in Golgi apparatus; axon cytoplasm; and cytoplasmic vesicle membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in postsynaptic recycling endosome. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 158.5), Lung (RPKM 156.6) and 9 other tissues See more
Orthologs
human mouse all
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See Ap3m1 in Genome Data Viewer
Location:
15p16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3285591..3314139)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3246616..3264846)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (3435998..3454281)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene adenosine kinase Neighboring gene uncharacterized LOC120097065 Neighboring gene uncharacterized LOC120097066 Neighboring gene vinculin Neighboring gene uncharacterized LOC120096900 Neighboring gene plasminogen activator, urokinase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex. Mardones GA, et al. J Biol Chem, 2013 Mar 29. PMID 23404500, Free PMC Article
  2. Direct interaction of Dysbindin with the AP-3 complex via its mu subunit. Taneichi-Kuroda S, et al. Neurochem Int, 2009 Jun. PMID 19428785
  3. Two rat homologs of clathrin-associated adaptor proteins. Pevsner J, et al. Gene, 1994 Sep 2. PMID 8076832
  4. BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles. Bultema JJ, et al. J Biol Chem, 2012 Jun 1. PMID 22511774, Free PMC Article
  5. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for the recognition of tyrosine-based sorting signals by the mu3A subunit of the AP-3 adaptor complex
    Title: Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde axonal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde synaptic vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
AP-3 complex subunit mu-1
Names
AP-3 adapter complex mu3A subunit
AP-3 adaptor complex mu3A subunit
HA1 47 kDa subunit homolog 1
Mu-adaptin 3A
adapter-related protein complex 3 mu-1 subunit
adapter-related protein complex 3 subunit mu-1
adaptor-related protein complex 3, mu 1 subunit
adaptor-related protein complex AP-3, mu 1 subunit
clathrin assembly protein assembly protein complex 1 medium chain homolog 1
clathrin assembly protein assembly protein complex 3 mu-1 medium chain
clathrin coat assembly protein AP47 homolog 1
clathrin coat-associated protein AP47 homolog 1
clathrin-associated adaptor protein homolog (p47A)
golgi adaptor AP-1 47 kDa protein homolog 1
mu3A-adaptin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133593.2 → NP_598277.2  AP-3 complex subunit mu-1

    See identical proteins and their annotated locations for NP_598277.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070925
    UniProtKB/Swiss-Prot
    P53676
    UniProtKB/TrEMBL
    A6KKR5, F7FH36, Q6IRG9
    Conserved Domains (2) summary
    cd09260
    Location:165 → 418
    AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    3285591..3314139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251630.5 → XP_006251692.2  AP-3 complex subunit mu-1 isoform X1

    Related
    ENSRNOP00000093883.2, ENSRNOT00000096809.2

  2. XM_006251629.4 → XP_006251691.1  AP-3 complex subunit mu-1 isoform X2

    See identical proteins and their annotated locations for XP_006251691.1

    UniProtKB/Swiss-Prot
    P53676
    UniProtKB/TrEMBL
    A6KKR5, F7FH36, Q6IRG9
    Conserved Domains (2) summary
    cd09260
    Location:165 → 418
    AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
    cd14837
    Location:3 → 141
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53676.1 GenPept UniProtKB/Swiss-Prot:P53676

Gene LinkOut

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