Ppp6c protein phosphatase 6, catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp6cprovided by RGD
Official Full Name: protein phosphatase 6, catalytic subunitprovided by RGD
Primary source: RGD:708460
See related: Ensembl:ENSRNOG00000015145 AllianceGenome:RGD:708460
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Muscle (RPKM 294.1), Kidney (RPKM 288.9) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 3q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (43339521..43371807, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (22929816..22962123, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:234385 (e-PCR)
- UniSTS:234385

RH130670 (e-PCR)
- UniSTS:213954

Ppp6c (e-PCR), detects polymorphism
- UniSTS:525266

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 6 catalytic subunit

Names: PP-V; PP6C; protein phosphatase V

NP_598273.2

EC 3.1.3.16

XP_017446937.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133589.2 → NP_598273.2 serine/threonine-protein phosphatase 6 catalytic subunit

See identical proteins and their annotated locations for NP_598273.2

Status: PROVISIONAL

Source sequence(s)

BC078747

UniProtKB/Swiss-Prot

Q64620, Q6AZ47

UniProtKB/TrEMBL

A0A8L2QAN5

Related

ENSRNOP00000021176.5, ENSRNOT00000021176.6

Conserved Domains (1) summary

cd07415
Location:5 → 289

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

43339521..43371807 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591448.3 → XP_017446937.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

UniProtKB/TrEMBL

A0ACJ1NAN1

Conserved Domains (1) summary

cl13995
Location:1 → 211

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain