Dusp5 dual specificity phosphatase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dusp5provided by RGD
Official Full Name: dual specificity phosphatase 5provided by RGD
Primary source: RGD:620854
See related: Ensembl:ENSRNOG00000014061 AllianceGenome:RGD:620854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cpg21
Summary: Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in negative regulation of transcription, DNA-templated; negative regulation of vasoconstriction; and positive regulation of cerebral blood circulation. Predicted to be active in cytoplasm and nucleus. Orthologous to human DUSP5 (dual specificity phosphatase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 46.3), Kidney (RPKM 37.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (262543774..262557201)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (252538408..252555320)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (274245184..274258595)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells.
Title: Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells.
MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by targeting DUSP5.
Title: MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by targeting DUSP5.
DUSP5 suppresses interleukin-1beta-induced chondrocyte inflammation and ameliorates osteoarthritis in rats.
Title: DUSP5 suppresses interleukin-1β-induced chondrocyte inflammation and ameliorates osteoarthritis in rats.
Influence of dual-specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles.
Title: Influence of dual-specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles.
Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1.
Title: Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1.
Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury
Title: Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury.
miR-32-5p promotes neuroinflammation and neuropathic pain development through regulation of Dusp5.
Title: miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain.
MeCP2 acts as a key regulator of pathological cardiac fibrosis, promotes cardiac fibroblasts proliferation and fibrosis by down-regulation of DUSP5.
Title: MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5.
Dusp5 modulates myogenic reactivity and autoregulation in the cerebral circulation.
Title: Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.
Data indicate that class I HDACs function as signal-dependent repressors of cardiac hypertrophy via inhibition of the gene encoding dual-specificity phosphatase 5 (DUSP5) DUSP5, a nuclear phosphatase that negatively regulates signaling by ERK1/2.
Title: Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endoderm formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cerebral blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dual specificity protein phosphatase 5

Names: MAP-kinase phosphatase (cpg21); MAP-kinase phosphatase CPG21; candidate plasticity-related gene 21

NP_598262.2

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133578.2 → NP_598262.2 dual specificity protein phosphatase 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O54838

UniProtKB/TrEMBL

F1LPJ5

Related

ENSRNOP00000018889.2, ENSRNOT00000018889.5

Conserved Domains (2) summary

cd01446
Location:5 → 140

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14639
Location:179 → 316

DSP_DUSP5; dual specificity phosphatase domain of dual specificity protein phosphatase 5