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Il17rc interleukin 17 receptor C [ Mus musculus (house mouse) ]

Gene ID: 171095, updated on 5-Mar-2024

Summary

Official Symbol
Il17rcprovided by MGI
Official Full Name
interleukin 17 receptor Cprovided by MGI
Primary source
MGI:MGI:2159336
See related
Ensembl:ENSMUSG00000030281 AllianceGenome:MGI:2159336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il17rl; Gm19850; IL-17RC; IL17-RC; IL17-RL; 1110025H02Rik
Summary
Enables signaling receptor binding activity. Involved in defense response to fungus; granulocyte chemotaxis; and positive regulation of interleukin-6 production. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response. Located in cell surface and plasma membrane. Is expressed in hip; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17RC (interleukin 17 receptor C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 138.6), duodenum adult (RPKM 133.9) and 12 other tissues See more
Orthologs
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Genomic context

See Il17rc in Genome Data Viewer
Location:
6 E3; 6 52.77 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113448416..113460124)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113471455..113483163)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8122 Neighboring gene jagunal homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113408068-113408221 Neighboring gene interleukin 17 receptor E Neighboring gene predicted gene, 52872 Neighboring gene STARR-positive B cell enhancer ABC_E684 Neighboring gene STARR-seq mESC enhancer starr_17041 Neighboring gene cysteine-rich with EGF-like domains 1 Neighboring gene proline-rich transmembrane protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables interleukin-17 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-17 receptor C
Names
IL-17 receptor C
IL-17RL
interleukin-17 receptor-like protein
zcytoR14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134159.4NP_598920.3  interleukin-17 receptor C isoform 2

    See identical proteins and their annotated locations for NP_598920.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AF458066, AI592368, AK075634, AW045329, BY018830
    Consensus CDS
    CCDS20422.1
    UniProtKB/TrEMBL
    F7AR97
    Related
    ENSMUSP00000055343.8, ENSMUST00000058300.14
    Conserved Domains (2) summary
    pfam08357
    Location:473623
    SEFIR; SEFIR domain
    pfam15037
    Location:71432
    IL17_R_N; Interleukin-17 receptor extracellular region
  2. NM_178942.1NP_849273.1  interleukin-17 receptor C isoform 1 precursor

    See identical proteins and their annotated locations for NP_849273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AF458066, AI592368, AK040950, AK075634, BY018830
    UniProtKB/Swiss-Prot
    G3X9C0, Q8K4C2, Q99J43
    UniProtKB/TrEMBL
    F7AR97
    Related
    ENSMUSP00000145038.2, ENSMUST00000205208.3
    Conserved Domains (2) summary
    pfam08357
    Location:497647
    SEFIR; SEFIR domain
    pfam15037
    Location:71456
    IL17_R_N; Interleukin-17 receptor extracellular region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113448416..113460124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505665.1XP_006505728.1  interleukin-17 receptor C isoform X1

    See identical proteins and their annotated locations for XP_006505728.1

    UniProtKB/TrEMBL
    F7AR97
    Conserved Domains (2) summary
    pfam08357
    Location:488638
    SEFIR; SEFIR domain
    pfam15037
    Location:71447
    IL17_R_N; Interleukin-17 receptor extracellular region
  2. XM_006505666.1XP_006505729.1  interleukin-17 receptor C isoform X2

    See identical proteins and their annotated locations for XP_006505729.1

    UniProtKB/TrEMBL
    F7AR97
    Conserved Domains (2) summary
    pfam08357
    Location:482632
    SEFIR; SEFIR domain
    pfam15037
    Location:71441
    IL17_R_N; Interleukin-17 receptor extracellular region
  3. XM_006505668.3XP_006505731.1  interleukin-17 receptor C isoform X4

    Conserved Domains (1) summary
    pfam15037
    Location:71371
    IL17_R_N; Interleukin-17 receptor extracellular region
  4. XM_006505667.4XP_006505730.1  interleukin-17 receptor C isoform X3

    Conserved Domains (1) summary
    pfam15037
    Location:71366
    IL17_R_N; Interleukin-17 receptor extracellular region

RNA

  1. XR_001785101.1 RNA Sequence