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Ppp1r15a protein phosphatase 1, regulatory subunit 15A [ Rattus norvegicus (Norway rat) ]

Gene ID: 171071, updated on 23-May-2018
Official Symbol
Ppp1r15aprovided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 15Aprovided by RGD
Primary source
RGD:621526
See related
Ensembl:ENSRNOG00000020938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Peg-3; Gadd34; Myd116; RGD1624209
Summary
displays increased expression during progression of transformation and in response to DNA damaging agents [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 157.5), Heart (RPKM 149.8) and 9 other tissues See more
Orthologs
See Ppp1r15a in Genome Data Viewer
Location:
1q22
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101511899..101515043, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (102590677..102593806, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene dihydrodiol dehydrogenase Neighboring gene tubby-like protein 2 Neighboring gene nucleobindin 1 Neighboring gene pleckstrin homology domain containing A4 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to calcium ion starvation IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to carbohydrate stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to cordycepin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to desipramine IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to gold(3+) IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to methamphetamine hydrochloride IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to methyl methanesulfonate IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to oxygen-glucose deprivation IEP
Inferred from Expression Pattern
more info
PubMed 
endoplasmic reticulum unfolded protein response IEP
Inferred from Expression Pattern
more info
PubMed 
endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation by eIF2 alpha dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to environmental enrichment IEP
Inferred from Expression Pattern
more info
PubMed 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein phosphatase 1 regulatory subunit 15A
Names
growth arrest and DNA damage-inducible protein GADD34
myeloid differentiation primary response gene 116
myeloid differentiation primary response protein MyD116 homolog
progression elevated gene 3 protein
protein phosphatase 1, regulatory (inhibitor) subunit 15A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133546.3NP_598230.2  protein phosphatase 1 regulatory subunit 15A

    See identical proteins and their annotated locations for NP_598230.2

    Status: VALIDATED

    Source sequence(s)
    AABR07071907, BC072513
    UniProtKB/Swiss-Prot
    Q6IN02
    UniProtKB/TrEMBL
    A0A0G2JSW4
    Related
    ENSRNOP00000048451.2, ENSRNOT00000044788.4
    Conserved Domains (1) summary
    pfam10488
    Location:459526
    PP1c_bdg; Phosphatase-1 catalytic subunit binding region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    101511899..101515043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228974.3XP_006229036.1  protein phosphatase 1 regulatory subunit 15A isoform X1

    Conserved Domains (1) summary
    pfam10488
    Location:420487
    PP1c_bdg; Phosphatase-1 catalytic subunit binding region

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    90255750..90258825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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