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Folr1 folate receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171049, updated on 27-Jan-2019

Summary

Official Symbol
Folr1provided by RGD
Official Full Name
folate receptor 1provided by RGD
Primary source
RGD:71032
See related
Ensembl:ENSRNOG00000019902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fbp1
Summary
mouse homolog plays a role in neural tube development [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 1929.3) and Testes (RPKM 104.7) See more
Orthologs

Genomic context

See Folr1 in Genome Data Viewer
Location:
1q32
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166934457..166945864, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (173124242..173135651, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene putative uncharacterized protein Neighboring gene 60S ribosomal protein L12-like Neighboring gene folate receptor beta Neighboring gene anaphase promoting complex subunit 15 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
drug binding ISO
Inferred from Sequence Orthology
more info
 
folic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
folic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
folic acid binding ISO
Inferred from Sequence Orthology
more info
 
folic acid receptor activity IEA
Inferred from Electronic Annotation
more info
 
folic acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
methotrexate binding IEA
Inferred from Electronic Annotation
more info
 
methotrexate binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anterior neural tube closure IEA
Inferred from Electronic Annotation
more info
 
anterior neural tube closure ISO
Inferred from Sequence Orthology
more info
 
axon regeneration IEA
Inferred from Electronic Annotation
more info
 
axon regeneration ISO
Inferred from Sequence Orthology
more info
 
cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to folic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to folic acid ISO
Inferred from Sequence Orthology
more info
 
folate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
folic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
folic acid transport ISO
Inferred from Sequence Orthology
more info
 
heart looping IEA
Inferred from Electronic Annotation
more info
 
heart looping ISO
Inferred from Sequence Orthology
more info
 
neural crest cell migration involved in heart formation IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration involved in heart formation ISO
Inferred from Sequence Orthology
more info
 
pharyngeal arch artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
response to axon injury ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
anchored component of external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anchored component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
brush border IDA
Inferred from Direct Assay
more info
PubMed 
brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
folate receptor alpha
Names
folate binding protein 1
folate receptor 1 (adult)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133527.2NP_598211.2  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AABR07004904, FM059473, FM060472
    UniProtKB/TrEMBL
    G3V8M6
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    166934457..166945864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588711.1XP_017444200.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    G3V8M6
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  2. XM_017588710.1XP_017444199.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    G3V8M6
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  3. XM_017588713.1XP_017444202.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    G3V8M6
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  4. XM_017588712.1XP_017444201.1  folate receptor alpha isoform X1

    UniProtKB/TrEMBL
    G3V8M6
    Related
    ENSRNOP00000026962.3, ENSRNOT00000026962.4
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  5. XM_006229842.3XP_006229904.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006229904.1

    UniProtKB/TrEMBL
    G3V8M6
    Related
    ENSRNOP00000071311.1, ENSRNOT00000079675.1
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    154298870..154310077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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