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ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif 19 [ Homo sapiens (human) ]

Gene ID: 171019, updated on 9-Jun-2020

Summary

Official Symbol
ADAMTS19provided by HGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 19provided by HGNC
Primary source
HGNC:HGNC:17111
See related
Ensembl:ENSG00000145808 MIM:607513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 3.1), placenta (RPKM 1.6) and 2 other tissues See more
Orthologs

Genomic context

See ADAMTS19 in Genome Data Viewer
Location:
5q23.3
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (129460281..129738683)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (128796103..129074376)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723654 Neighboring gene uncharacterized LOC105379169 Neighboring gene ADAMTS19 antisense RNA 1 Neighboring gene microRNA 4460 Neighboring gene membrane integral NOTCH2 associated receptor 2 Neighboring gene uncharacterized LOC112267944 Neighboring gene chondroitin sulfate synthase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of ADAM metallopeptidase with thrombospondin type 1 motif 19 protein (ADAMTS19) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • FLJ16042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 19
Names
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133638.6NP_598377.4  A disintegrin and metalloproteinase with thrombospondin motifs 19

    Status: REVIEWED

    Source sequence(s)
    AC008425, AC008528, AC008591, AC106781, AC129713
    Consensus CDS
    CCDS4146.2
    UniProtKB/Swiss-Prot
    Q8TE59
    UniProtKB/TrEMBL
    A0A1X7SBR9
    Related
    ENSP00000274487.5, ENST00000274487.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    129460281..129738683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543248.2XP_011541550.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X3

    See identical proteins and their annotated locations for XP_011541550.1

    Conserved Domains (4) summary
    smart00209
    Location:246295
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:399520
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:791816
    PLAC; PLAC (protease and lacunin) domain
    cl00064
    Location:1147
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. XM_011543246.2XP_011541548.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X1

    Conserved Domains (5) summary
    smart00209
    Location:403452
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:87304
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:89305
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam05986
    Location:556677
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:948973
    PLAC; PLAC (protease and lacunin) domain
  3. XM_017009176.1XP_016864665.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X5

  4. XM_011543247.2XP_011541549.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X3

    See identical proteins and their annotated locations for XP_011541549.1

    Conserved Domains (4) summary
    smart00209
    Location:246295
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:399520
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:791816
    PLAC; PLAC (protease and lacunin) domain
    cl00064
    Location:1147
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  5. XM_017009174.1XP_016864663.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X2

  6. XM_017009175.1XP_016864664.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X4

    Conserved Domains (4) summary
    smart00209
    Location:199248
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:352473
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:744769
    PLAC; PLAC (protease and lacunin) domain
    cl00064
    Location:6100
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  7. XM_011543249.2XP_011541551.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X4

    Conserved Domains (4) summary
    smart00209
    Location:199248
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:352473
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:744769
    PLAC; PLAC (protease and lacunin) domain
    cl00064
    Location:6100
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
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