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ZNF721 zinc finger protein 721 [ Homo sapiens (human) ]

Gene ID: 170960, updated on 13-May-2022

Summary

Official Symbol
ZNF721provided by HGNC
Official Full Name
zinc finger protein 721provided by HGNC
Primary source
HGNC:HGNC:29425
See related
Ensembl:ENSG00000182903 AllianceGenome:HGNC:29425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.9), lymph node (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF721 in Genome Data Viewer
Location:
4p16.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (439988..499156, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (433383..492537, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (433777..492945, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 519 pseudogene 4 Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene ATP binding cassette subfamily A member 11, pseudogene Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene phosphatidylinositol glycan anchor biosynthesis class G Neighboring gene transmembrane protein 271

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11452, KIAA1982

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133474.4NP_597731.2  zinc finger protein 721

    Status: VALIDATED

    Source sequence(s)
    AC092574, AI223001, DA309597, HY075884
    Consensus CDS
    CCDS46991.1
    UniProtKB/Swiss-Prot
    Q8TF20
    Related
    ENSP00000428878.1, ENST00000511833.3
    Conserved Domains (3) summary
    COG5048
    Location:442885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:279299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:151176
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    439988..499156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    433383..492537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)