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PPP1R18 protein phosphatase 1 regulatory subunit 18 [ Homo sapiens (human) ]

Gene ID: 170954, updated on 7-Jun-2020

Summary

Official Symbol
PPP1R18provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 18provided by HGNC
Primary source
HGNC:HGNC:29413
See related
Ensembl:ENSG00000146112 MIM:610990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HKMT1098; KIAA1949
Summary
Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in lymph node (RPKM 31.8), appendix (RPKM 27.5) and 24 other tissues See more
Orthologs

Genomic context

See PPP1R18 in Genome Data Viewer
Location:
6p21.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30676389..30687207, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30644166..30655672, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1 Neighboring gene chromosome 6 open reading frame 136 Neighboring gene DEAH-box helicase 16 Neighboring gene Sharpr-MPRA regulatory region 567 Neighboring gene nurim Neighboring gene ribosomal protein L7 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phostensin
Names
protein phosphatase 1 F-actin cytoskeleton targeting subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134870.2NP_001128342.1  phostensin

    See identical proteins and their annotated locations for NP_001128342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC006176, BX647622
    Consensus CDS
    CCDS43444.1
    UniProtKB/Swiss-Prot
    Q6NYC8
    UniProtKB/TrEMBL
    A0A024RCJ8
    Related
    ENSP00000382150.3, ENST00000399199.7
    Conserved Domains (2) summary
    pfam13914
    Location:450560
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:28116
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal
  2. NM_133471.4NP_597728.1  phostensin

    See identical proteins and their annotated locations for NP_597728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB075829, BC006176
    Consensus CDS
    CCDS43444.1
    UniProtKB/Swiss-Prot
    Q6NYC8
    UniProtKB/TrEMBL
    A0A024RCJ8
    Related
    ENSP00000274853.3, ENST00000274853.8
    Conserved Domains (2) summary
    pfam13914
    Location:450560
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:28116
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30676389..30687207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2005896..2016714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2156133..2166951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1932243..1943061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1986642..1997460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    2020466..2031284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1931503..1942321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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