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Sumo2 small ubiquitin-like modifier 2 [ Mus musculus (house mouse) ]

Gene ID: 170930, updated on 26-Sep-2022

Summary

Official Symbol
Sumo2provided by MGI
Official Full Name
small ubiquitin-like modifier 2provided by MGI
Primary source
MGI:MGI:2158813
See related
Ensembl:ENSMUSG00000020738 AllianceGenome:MGI:2158813
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smt3A; Smt3b; SUMO-2; Smt3h2
Summary
Enables SUMO transferase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; eye; heart; and metanephros. Orthologous to human SUMO2 (small ubiquitin like modifier 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 246.7), CNS E14 (RPKM 206.8) and 20 other tissues See more
Orthologs
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Genomic context

See Sumo2 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115413935..115427056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115523109..115536230, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene Neighboring gene 5',3'-nucleotidase, cytosolic Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene predicted gene, 25364

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
small ubiquitin-related modifier 2
Names
SMT3 homolog 2
SMT3 suppressor of mif two 3 homolog 2
SMT3 supressor of mif two 3 homolog 2
sentrin-2
ubiquitin-like protein SMT3A
ubiquitin-like protein SMT3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133354.2NP_579932.1  small ubiquitin-related modifier 2

    See identical proteins and their annotated locations for NP_579932.1

    Status: PROVISIONAL

    Source sequence(s)
    AK012619
    Consensus CDS
    CCDS36374.1
    UniProtKB/Swiss-Prot
    P61957, Q542L8
    UniProtKB/TrEMBL
    A0A6P5QU51, A0A8C6HG09
    Related
    ENSMUSP00000115044.2, ENSMUST00000153892.2
    Conserved Domains (1) summary
    cd16115
    Location:1788
    Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115413935..115427056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)