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Abcb1a ATP binding cassette subfamily B member 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 170913, updated on 10-Feb-2026
Official Symbol
Abcb1aprovided by RGD
Official Full Name
ATP binding cassette subfamily B member 1Aprovided by RGD
Primary source
RGD:619951
See related
Ensembl:ENSRNOG00000008012 AllianceGenome:RGD:619951
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Abcb1; Mdr1a
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to L-glutamate; and cellular response to borneol. Located in apical plasma membrane and brush border membrane. Biomarker of brain disease (multiple); end stage renal disease; human immunodeficiency virus infectious disease; liver disease (multiple); and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Liver (RPKM 100.7), Kidney (RPKM 76.4) and 9 other tissues See more
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Try the new Transcripts and proteins table
See Abcb1a in Genome Data Viewer
Location:
4q12
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26312403..26488456, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25357467..25529941, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22339829..22517642, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene uncharacterized LOC120102221 Neighboring gene ATP binding cassette subfamily B member 4 Neighboring gene uncharacterized LOC120102222 Neighboring gene ATP-binding cassette, sub-family B member 1B Neighboring gene RUN domain containing 3B Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4-CDC7 kinase regulatory subunit

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein (PGP) expression in asthmatic children. Kopriva F, et al. J Asthma, 2009 May. PMID 19484671
  2. Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse. Booth-Genthe CL, et al. J Pharmacol Toxicol Methods, 2006 Jul-Aug. PMID 16545584
  3. 5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better? Tsartsalis S, et al. Nucl Med Biol, 2016 Jan. PMID 26454782
  4. Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney. Uchida Y, et al. J Pharm Sci, 2016 Feb. PMID 26367854
  5. Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. Hassan HE, et al. J Pharm Sci, 2007 Sep. PMID 17593551, Free PMC Article

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
    Title: Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
  2. Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
    Title: Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
  3. Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats.
    Title: Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats.
  4. Galactosemia caused the osmotic stress in lenses; it also markedly leads to the upregulations of aldose reductase, P-glycoprotein, and Clcn3 in lens epithelial cells, together resulting in obvious osmotic expansion in vitro and in vivo.
    Title: Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract.
  5. Abcb1a is critical in maintaining blood-testis barrier integrity, while Abcb1b is crucial for junction reassembly at the blood-testis barrier.
    Title: Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat.
  6. The placenta and maternal/fetal intestine, brain, kidneys and liver were sampled and analysed for Abcb1a, Abcb1b and Abcg2 expression.
    Title: Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs.
  7. Study demonstrates that P-GP expression and function may be altered in cerebral cortex, hippocampus, liver and kidney of rats under the vitamin A deficiency condition.
    Title: The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo.
  8. The data indicate that Pgp and Bcrp do not play significant roles in drug distribution into peripheral nerve tissues in rats, while working in concert to regulate brain penetration.
    Title: Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.
  9. Both relative liver and kidney weights were higher in Mdr1a (and Mrp2)knockout animals.
    Title: Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
  10. Report drug metabolizing phenotype of Mdr1a knockout rats.
    Title: Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
Submit: New GeneRIF Correction See all GeneRIFs (19)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
ATP binding cassette subfamily B member 1A
Names
ATP binding cassette subfamily B member 1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
ATP-binding cassette, subfamily B (MDR/TAP), member 1A
multiple drug resistant 1a

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133401.2 → NP_596892.1  ATP binding cassette subfamily B member 1A

    See identical proteins and their annotated locations for NP_596892.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A9K3Y745, A0ABK0KW61, Q6PSM0
    Related
    ENSRNOP00000098458.1, ENSRNOT00000120846.2
    Conserved Domains (3) summary
    cd03249
    Location:385 → 621
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:51 → 1259
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:54 → 335
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    26312403..26488456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235994.5 → XP_006236056.1  ATP binding cassette subfamily B member 1A isoform X1

    See identical proteins and their annotated locations for XP_006236056.1

    UniProtKB/TrEMBL
    A0A9K3Y745, A0ABK0KW61, Q6PSM0
    Conserved Domains (3) summary
    cd03249
    Location:385 → 621
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:51 → 1259
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:54 → 335
    ABC_membrane; ABC transporter transmembrane region

  2. XM_063285445.1 → XP_063141515.1  ATP binding cassette subfamily B member 1A isoform X2

    UniProtKB/TrEMBL
    Q6PSM0
    Related
    ENSRNOP00000042556.2, ENSRNOT00000043822.3
Nucleotide Protein Strain
Heading Accession and Version

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