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Kcnq2 potassium voltage-gated channel subfamily Q member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170848, updated on 4-Jun-2017
Official Symbol
Kcnq2provided by RGD
Official Full Name
potassium voltage-gated channel subfamily Q member 2provided by RGD
Primary source
RGD:621504
See related
Ensembl:ENSRNOG00000011624
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
potassium channel involved in sympathetic neuronal excitability [RGD, Feb 2006]
Orthologs
Location:
3q43
Exon count:
18
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176585897..176645029, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (180295948..180355064, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene collagen type XX alpha 1 chain Neighboring gene uncharacterized LOC102546950 Neighboring gene cholinergic receptor nicotinic alpha 4 subunit Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene uncharacterized LOC108350540 Neighboring gene pancreatic progenitor cell differentiation and proliferation factor

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ankyrin binding IEA
Inferred from Electronic Annotation
more info
 
ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon initial segment ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
node of Ranvier ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
potassium voltage-gated channel subfamily KQT member 2
Names
KQT-like 2
potassium channel subunit alpha KvLQT2
potassium channel, voltage-gated KQT-like subfamily Q, member 2
potassium voltage-gated channel, KQT-like subfamily, member 2
voltage-gated potassium channel subunit Kv7.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133322.1NP_579856.1  potassium voltage-gated channel subfamily KQT member 2

    See identical proteins and their annotated locations for NP_579856.1

    Status: PROVISIONAL

    Source sequence(s)
    AF087453
    UniProtKB/Swiss-Prot
    O88943
    Related
    ENSRNOP00000040830.3, ENSRNOT00000049961.4
    Conserved Domains (5) summary
    pfam00520
    Location:119324
    Ion_trans; Ion transport protein
    pfam03520
    Location:454640
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240314
    Ion_trans_2; Ion channel
    pfam11956
    Location:758848
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:649736
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    176585897..176645029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591441.1XP_017446930.1  potassium voltage-gated channel subfamily KQT member 2 isoform X2

  2. XM_017591445.1XP_017446934.1  potassium voltage-gated channel subfamily KQT member 2 isoform X8

  3. XM_006235729.3XP_006235791.1  potassium voltage-gated channel subfamily KQT member 2 isoform X10

    Conserved Domains (5) summary
    pfam00520
    Location:119324
    Ion_trans; Ion transport protein
    pfam03520
    Location:444630
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240314
    Ion_trans_2; Ion channel
    pfam11956
    Location:748838
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:639726
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
  4. XM_006235725.3XP_006235787.1  potassium voltage-gated channel subfamily KQT member 2 isoform X5

    Conserved Domains (5) summary
    pfam00520
    Location:119324
    Ion_trans; Ion transport protein
    pfam03520
    Location:444666
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240314
    Ion_trans_2; Ion channel
    pfam11956
    Location:784874
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:675762
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
  5. XM_017591442.1XP_017446931.1  potassium voltage-gated channel subfamily KQT member 2 isoform X3

  6. XM_017591447.1XP_017446936.1  potassium voltage-gated channel subfamily KQT member 2 isoform X11

  7. XM_017591444.1XP_017446933.1  potassium voltage-gated channel subfamily KQT member 2 isoform X6

  8. XM_017591446.1XP_017446935.1  potassium voltage-gated channel subfamily KQT member 2 isoform X9

  9. XM_017591443.1XP_017446932.1  potassium voltage-gated channel subfamily KQT member 2 isoform X4

  10. XM_006235727.3XP_006235789.1  potassium voltage-gated channel subfamily KQT member 2 isoform X7

    Conserved Domains (5) summary
    pfam00520
    Location:119324
    Ion_trans; Ion transport protein
    pfam03520
    Location:472658
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240314
    Ion_trans_2; Ion channel
    pfam11956
    Location:776866
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:667754
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
  11. XM_006235721.3XP_006235783.1  potassium voltage-gated channel subfamily KQT member 2 isoform X1

    Conserved Domains (5) summary
    pfam00520
    Location:119324
    Ion_trans; Ion transport protein
    pfam03520
    Location:472694
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240314
    Ion_trans_2; Ion channel
    pfam11956
    Location:812902
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:703790
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
  12. XM_008762462.2XP_008760684.1  potassium voltage-gated channel subfamily KQT member 2 isoform X12

    Conserved Domains (3) summary
    pfam00520
    Location:119324
    Ion_trans; Ion transport protein
    pfam03520
    Location:472618
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240314
    Ion_trans_2; Ion channel

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    164332108..164387022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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