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Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta [ Mus musculus (house mouse) ]

Gene ID: 170826, updated on 12-May-2024

Summary

Official Symbol
Ppargc1bprovided by MGI
Official Full Name
peroxisome proliferative activated receptor, gamma, coactivator 1 betaprovided by MGI
Primary source
MGI:MGI:2444934
See related
Ensembl:ENSMUSG00000033871 AllianceGenome:MGI:2444934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Perc; PGC-1beta; 4631412G21Rik; PPARGC-1-beta; PGC-1beta/ERRL1
Summary
Predicted to enable AF-2 domain binding activity; estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in several processes, including bone trabecula formation; positive regulation of phosphate metabolic process; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in brown fat; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 4.4), colon adult (RPKM 3.6) and 24 other tissues See more
Orthologs
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Genomic context

See Ppargc1b in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61424516..61533846, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61291445..61400756, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7591 Neighboring gene solute carrier family 26 (sulfate transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_44740 Neighboring gene predicted gene, 52353 Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene STARR-seq mESC enhancer starr_44743 Neighboring gene ribosomal protein S2, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_44744 Neighboring gene predicted gene, 46627 Neighboring gene STARR-positive B cell enhancer ABC_E10995 Neighboring gene microRNA 378a Neighboring gene predicted gene, 52354 Neighboring gene predicted gene 8755 Neighboring gene predicted gene, 25834

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (11)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AF-2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of alkaline phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma coactivator 1-beta
Names
ERR ligand 1
PPAR gamma coactivator-1beta protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364996.1NP_001351925.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116595, AC121903
    Consensus CDS
    CCDS89250.1
    UniProtKB/TrEMBL
    B2RWT8
    Related
    ENSMUSP00000069431.6, ENSMUST00000063307.6
    Conserved Domains (2) summary
    cd12356
    Location:907986
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins
    cl28087
    Location:178443
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  2. NM_133249.3NP_573512.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1

    See identical proteins and their annotated locations for NP_573512.1

    Status: VALIDATED

    Source sequence(s)
    AC116595, AC121903
    Consensus CDS
    CCDS29284.1
    UniProtKB/Swiss-Prot
    Q8C1C0, Q8VHJ7
    UniProtKB/TrEMBL
    B2RWT8
    Related
    ENSMUSP00000074771.7, ENSMUST00000075299.13
    Conserved Domains (1) summary
    cd12356
    Location:891970
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61424516..61533846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525698.4XP_006525761.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1

    UniProtKB/TrEMBL
    B2RWT8
    Conserved Domains (2) summary
    PRK10263
    Location:194459
    PRK10263; DNA translocase FtsK; Provisional
    cd12356
    Location:9231002
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins