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Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta [ Mus musculus (house mouse) ]

Gene ID: 170826, updated on 22-Nov-2020

Summary

Official Symbol
Ppargc1bprovided by MGI
Official Full Name
peroxisome proliferative activated receptor, gamma, coactivator 1 betaprovided by MGI
Primary source
MGI:MGI:2444934
See related
Ensembl:ENSMUSG00000033871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Perc; PGC-1beta; 4631412G21Rik; PPARGC-1-beta; PGC-1beta/ERRL1
Expression
Broad expression in cerebellum adult (RPKM 4.4), colon adult (RPKM 3.6) and 24 other tissues See more
Orthologs

Genomic context

See Ppargc1b in Genome Data Viewer
Location:
18; 18 E1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61424516..61533846, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61291445..61400756, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (61457790..61560085, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 (sulfate transporter), member 2 Neighboring gene predicted gene, 52353 Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene ribosomal protein S2, pseudogene 10 Neighboring gene predicted gene, 46627 Neighboring gene microRNA 378a Neighboring gene predicted gene, 52354 Neighboring gene predicted gene 8755 Neighboring gene predicted gene, 25834

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AF-2 domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of alkaline phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mediator complex ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma coactivator 1-beta
Names
ERR ligand 1
PPAR gamma coactivator-1beta protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364996.1NP_001351925.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116595, AC121903
    Consensus CDS
    CCDS89250.1
    Related
    ENSMUSP00000069431.5, ENSMUST00000063307.5
    Conserved Domains (2) summary
    cd12356
    Location:907986
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins
    cl28087
    Location:178443
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  2. NM_133249.3NP_573512.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1

    See identical proteins and their annotated locations for NP_573512.1

    Status: VALIDATED

    Source sequence(s)
    AC116595, AC121903
    Consensus CDS
    CCDS29284.1
    UniProtKB/Swiss-Prot
    Q8VHJ7
    Related
    ENSMUSP00000074771.6, ENSMUST00000075299.12
    Conserved Domains (1) summary
    cd12356
    Location:891970
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61424516..61533846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525698.4XP_006525761.1  peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1

    Conserved Domains (1) summary
    cd12356
    Location:9231002
    RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins
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