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Glmn glomulin, FKBP associated protein [ Mus musculus (house mouse) ]

Gene ID: 170823, updated on 12-May-2024

Summary

Official Symbol
Glmnprovided by MGI
Official Full Name
glomulin, FKBP associated proteinprovided by MGI
Primary source
MGI:MGI:2141180
See related
Ensembl:ENSMUSG00000029276 AllianceGenome:MGI:2141180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fap48; Fap68; 9330160J16Rik
Summary
Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Acts upstream of or within circulatory system development and neural tube closure. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including arterial system; respiratory system; skeleton; skin; and urinary system. Human ortholog(s) of this gene implicated in arteriovenous malformation and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.4), CNS E18 (RPKM 3.9) and 20 other tissues See more
Orthologs
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Genomic context

See Glmn in Genome Data Viewer
Location:
5 F; 5 52.23 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107696828..107745754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107548962..107597888, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 8 Neighboring gene predicted gene, 33885 Neighboring gene LSM12 homolog pseudogene Neighboring gene RIKEN cDNA 1700028K03 gene Neighboring gene STARR-seq mESC enhancer starr_13890 Neighboring gene STARR-positive B cell enhancer ABC_E1683 Neighboring gene RNA polymerase II associated protein 2 Neighboring gene RIKEN cDNA A930041C12 gene Neighboring gene Gfi1 +35 kb enhancer Neighboring gene RIKEN cDNA 4930428O21 gene Neighboring gene +19.5 kb enhancer downstream of Gfi1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6885

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hepatocyte growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glomulin
Names
FAP
FK506-binding protein-associated protein
FKBP-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161738.1NP_001155210.1  glomulin isoform a

    See identical proteins and their annotated locations for NP_001155210.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC134411, AK034160
    Consensus CDS
    CCDS19505.1
    UniProtKB/Swiss-Prot
    Q3TFR5, Q8BZM1, Q99LB8
    UniProtKB/TrEMBL
    Q3TMW7
    Related
    ENSMUSP00000080766.3, ENSMUST00000082121.9
    Conserved Domains (1) summary
    pfam08568
    Location:1527
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
  2. NM_001161739.1NP_001155211.1  glomulin isoform b

    See identical proteins and their annotated locations for NP_001155211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC117574, AC134411, AK169045
    Consensus CDS
    CCDS51587.1
    UniProtKB/TrEMBL
    Q3T9A5, Q3TMW7
    Related
    ENSMUSP00000098509.4, ENSMUST00000100949.10
    Conserved Domains (1) summary
    pfam08568
    Location:1462
    Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin
  3. NM_133248.2NP_573511.2  glomulin isoform a

    See identical proteins and their annotated locations for NP_573511.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC134411, AK169045, BY013339
    Consensus CDS
    CCDS19505.1
    UniProtKB/Swiss-Prot
    Q3TFR5, Q8BZM1, Q99LB8
    UniProtKB/TrEMBL
    Q3TMW7
    Related
    ENSMUSP00000077168.7, ENSMUST00000078021.13
    Conserved Domains (1) summary
    pfam08568
    Location:1527
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107696828..107745754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249410.3XP_011247712.1  glomulin isoform X2

    Conserved Domains (1) summary
    pfam08568
    Location:14224
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
  2. XM_030254179.1XP_030110039.1  glomulin isoform X2

    Conserved Domains (1) summary
    pfam08568
    Location:14224
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
  3. XM_006534800.5XP_006534863.1  glomulin isoform X1

    See identical proteins and their annotated locations for XP_006534863.1

    UniProtKB/Swiss-Prot
    Q3TFR5, Q8BZM1, Q99LB8
    UniProtKB/TrEMBL
    Q3TMW7
    Conserved Domains (1) summary
    pfam08568
    Location:1527
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
  4. XM_017320694.3XP_017176183.1  glomulin isoform X2

    Conserved Domains (1) summary
    pfam08568
    Location:14224
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

RNA

  1. XR_001784631.2 RNA Sequence

    Related
    ENSMUST00000124546.8