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Usp33 ubiquitin specific peptidase 33 [ Mus musculus (house mouse) ]

Gene ID: 170822, updated on 22-Apr-2024

Summary

Official Symbol
Usp33provided by MGI
Official Full Name
ubiquitin specific peptidase 33provided by MGI
Primary source
MGI:MGI:2159711
See related
Ensembl:ENSMUSG00000025437 AllianceGenome:MGI:2159711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vdu1; 9830169D19Rik
Summary
Predicted to enable several functions, including cysteine-type peptidase activity; small GTPase binding activity; and zinc ion binding activity. Involved in axon guidance and cell migration. Located in cell body. Is expressed in central nervous system and retina. Orthologous to human USP33 (ubiquitin specific peptidase 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 26.3), CNS E14 (RPKM 24.1) and 25 other tissues See more
Orthologs
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Genomic context

Location:
3 H3; 3 77.15 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152051797..152099254)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152346184..152393617)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31999 Neighboring gene VISTA enhancer mm72 Neighboring gene mitoguardin 1 Neighboring gene zinc finger, ZZ domain containing 3 Neighboring gene predicted gene, 57837 Neighboring gene RIKEN cDNA 3110067G11 gene Neighboring gene STARR-positive B cell enhancer ABC_E4606 Neighboring gene adenylate kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 33
Names
VHL-interacting deubiquitinating enzyme 1
Vhlh-interacting deubiquitinating enzyme 1
deubiquitinating enzyme 33
pVHL-interacting deubiquitinating enzyme 1
ubiquitin specific protease 33
ubiquitin thioesterase 33
ubiquitin thiolesterase 33
ubiquitin-specific-processing protease 33
NP_001070144.1
NP_001239415.1
NP_001342595.1
NP_573510.2
XP_030108303.1
XP_030108304.1
XP_036018806.1
XP_036018807.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076676.2NP_001070144.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice junctions compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AA210301, AK082943, AK087467
    Consensus CDS
    CCDS80064.1
    UniProtKB/TrEMBL
    A0A0H2UKB8, Q80TK2
    Related
    ENSMUSP00000026507.8, ENSMUST00000026507.13
    Conserved Domains (6) summary
    smart00695
    Location:799879
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:441672
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:155287
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:153671
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:693762
    DUSP; DUSP domain
  2. NM_001252486.1NP_001239415.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1, resulting in a shorter protein (isoform 3).
    Source sequence(s)
    AA210301, AK087467, AK143844, BC089315
    Consensus CDS
    CCDS57261.1
    UniProtKB/TrEMBL
    Q80TK2
    Related
    ENSMUSP00000113265.4, ENSMUST00000117492.9
    Conserved Domains (6) summary
    smart00695
    Location:799883
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:441672
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:155287
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:153671
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:693762
    DUSP; DUSP domain
  3. NM_001355666.1NP_001342595.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA210301, AC122529
    UniProtKB/TrEMBL
    Q80TK2
    Conserved Domains (3) summary
    pfam00443
    Location:154679
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:701764
    DUSP; DUSP domain
  4. NM_133247.3NP_573510.2  ubiquitin carboxyl-terminal hydrolase 33 isoform 1

    See identical proteins and their annotated locations for NP_573510.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA210301, AK087467, AK143844, BC089315
    Consensus CDS
    CCDS17918.1
    UniProtKB/Swiss-Prot
    Q3UP32, Q5FWK0, Q8K0I3, Q8R5K2, Q99K22
    UniProtKB/TrEMBL
    Q80TK2
    Related
    ENSMUSP00000142708.2, ENSMUST00000197748.5
    Conserved Domains (4) summary
    smart00695
    Location:807891
    DUSP; Domain in ubiquitin-specific proteases
    pfam00443
    Location:154679
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:701770
    DUSP; DUSP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    152051797..152099254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162913.1XP_036018806.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

    UniProtKB/TrEMBL
    Q80TK2
    Conserved Domains (3) summary
    pfam00443
    Location:154679
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:701770
    DUSP; DUSP domain
  2. XM_036162914.1XP_036018807.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

    UniProtKB/TrEMBL
    Q80TK2
    Conserved Domains (3) summary
    pfam00443
    Location:154671
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:693762
    DUSP; DUSP domain
  3. XM_030252444.2XP_030108304.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X4

    UniProtKB/TrEMBL
    Q80TK2
    Conserved Domains (3) summary
    pfam00443
    Location:154671
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:693756
    DUSP; DUSP domain
  4. XM_030252443.2XP_030108303.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q3UP32, Q5FWK0, Q8K0I3, Q8R5K2, Q99K22
    UniProtKB/TrEMBL
    Q80TK2
    Conserved Domains (4) summary
    smart00695
    Location:807891
    DUSP; Domain in ubiquitin-specific proteases
    pfam00443
    Location:154679
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:701770
    DUSP; DUSP domain